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Unified Medical Language System® (UMLS®)

RxNorm Release Notes

June Release - 06/05/2017

This release of RxNorm is consistent with the 2017AA UMLS Metathesaurus release. For additional information about RxNorm releases, including scripts for loading the RxNorm data into Oracle and MySQL databases, read the RxNorm technical documentation.

Sources

The following sources have been updated since the previous RxNorm release:

Source NameSABVersion
Vaccines Administered CVX CVX_2017_05_03
DrugBank DRUGBANK DRUGBANK5.0_2017_04_28
Gold Standard Drug Database GS GS_2017_05_01
Medi-Span Master Drug Data Base MDDB MDDB_2017_05_03
Multum MediSource Lexicon MMSL MMSL_2017_05_01
Micromedex RED BOOK MMX MMX_2017_05_01
FDA Structured Product Labels MTHSPL MTHSPL_2017_05_26
FDB MedKnowledge (formerly NDDF Plus) NDDF NDDF_2017_05_03
Veterans Health Administration National Drug File - Reference Terminology NDFRT NDFRT_2017_06_05
NDFRT FDASPL relationships NDFRT_FDASPL NDFRT_FDASPL_2017_06_05
NDFRT FMTSME relationships NDFRT_FMTSME NDFRT_FMTSME_2017_06_05
Veterans Health Administration National Drug File VANDF VANDF_2017_04_24

 

The following sources have not been updated in this release:

Source NameSABVersion
Anatomical Therapeutic Chemical Classification System ATC ATC_2017
CMS Formulary Reference File MTHCMSFRF MTHCMSFRF_2014
Medical Subject Headings (MeSH) MSH MSH2017_2017_02_14
US Edition of SNOMED CT (drug information) SNOMEDCT_US SNOMEDCT_US_2017_01_31

Data Changes

Data Error
Six RXCUIs (1088899, 1562, 219009, 236117, 314522, 582031) were incorrectly mapped to RXCUI 350141 and appeared in the June RXNCUICHANGES.RRF file. This error will be corrected in the July monthly release. The six RXCUIs that were incorrectly mapped will be archived and will appear in the RXNATOMARCHIVE.RRF file for the monthly release in July.

Qualitative Distinction
Please see the technical documentation for an explanation of Qualitative Distinctions (QDs), which were first released in the August monthly release.

Here are the new concepts with QDs in the June release:

RXCUITTYString
1922877SBDPreservative-Free Timolol 2.5 MG/ML Ophthalmic Solution [Timoptic]
1922895SBDPreservative-Free Timolol 5 MG/ML Ophthalmic Solution [Timoptic]
1922784SBDPreservative-Free dorzolamide 20 MG/ML / Timolol 5 MG/ML Ophthalmic Solution [Cosopt]
1922876SCDPreservative-Free Timolol 2.5 MG/ML Ophthalmic Solution
1922894SCDPreservative-Free Timolol 5 MG/ML Ophthalmic Solution
1922783SCDPreservative-Free dorzolamide 20 MG/ML / Timolol 5 MG/ML Ophthalmic Solution
1922721SBDAtrial Fibrillation Sotalol Hydrochloride 120 MG Oral Tablet [Betapace]
1922764SBDAtrial Fibrillation Sotalol Hydrochloride 160 MG Oral Tablet [Betapace]
1922766SBDAtrial Fibrillation Sotalol Hydrochloride 80 MG Oral Tablet [Betapace]
1922720SCDAtrial Fibrillation Sotalol Hydrochloride 120 MG Oral Tablet
1922763SCDAtrial Fibrillation Sotalol Hydrochloride 160 MG Oral Tablet
1922765SCDAtrial Fibrillation Sotalol Hydrochloride 80 MG Oral Tablet

For each SCD or SBD with a QD, there is an associated attribute in RXNSAT with the attribute name (ATN) of 'RXN_QUALITATIVE_DISTINCTION'. The June release contains the following new attributes to match the QD strings found in the SCD and SBD normalized names:

  • Preservative-Free
  • Atrial Fibrillation

New RXCUI for Same Normal Form when Concept Meaning Changes
RxNorm now creates a new concept unique identifier (RXCUI) for an existing RxNorm normalized name to reflect a change in the drug product represented. In the past, RxNorm minimized changes to RXCUIs; however, beginning with the June 2017 release, RXCUIs can change for an existing RxNorm normalized name. The concepts most impacted will be the concepts that group drugs together that need to have separate RXCUIs. When the original concept is split to represent distinct drugs with unique RXCUIs, the original RXCUI will be archived and replaced with a new RXCUI if the original normalized name is retained.

For example, in the May 2017 release, RXCUI 904603 with SBD = Sotalol Hydrochloride 80 MG Oral Tablet [Betapace], represented two separate drugs: Betapace 80 MG Oral Tablet -OR- Betapace AF 80 MG Oral Tablet.

The May 2017 RxNorm Release included the following concept:

RXCUITTYString
904603SBDSotalol Hydrochloride 80 MG Oral Tablet [Betapace]

In the June 2017 release, the RxNorm editing team split RXCUI 904603, creating a new concept RXCUI 1923427 with SBD = Atrial Fibrillation Sotalol Hydrochloride 80 MG Oral Tablet [Betapace]), leaving the original concept to represent only one drug, Betapace 80 MG Oral Tablet.

The June 2017 RxNorm Release included the following two concepts with new RXCUIs:

RXCUITTYString
1923427SBDSotalol Hydrochloride 80 MG Oral Tablet [Betapace]
1922766SBDAtrial Fibrillation Sotalol Hydrochloride 80 MG Oral Tablet [Betapace]

To reflect the change in meaning to RXCUI 904603 in the June release, the original RXCUI 904603 was archived and a new RxCUI 1923427 was created while keeping the original normalized name.

The June 2017 release includes new RXCUIs for the following active concepts:

RXCUI1 (old)RXCUI2 (new)TTYSTR
6706401923429SBDTimolol 2.5 MG/ML Ophthalmic Solution [Timoptic]
6706461923431SBDTimolol 5 MG/ML Ophthalmic Solution [Timoptic]
1982831923428SCDTimolol 2.5 MG/ML Ophthalmic Solution
3134091923430SCDTimolol 5 MG/ML Ophthalmic Solution
2132801923433SBDdorzolamide 20 MG/ML / Timolol 5 MG/ML Ophthalmic Solution [Cosopt]
3139541923432SCDdorzolamide 20 MG/ML / Timolol 5 MG/ML Ophthalmic Solution
9045691923423SBDSotalol Hydrochloride 160 MG Oral Tablet [Betapace]
9045811923425SBDSotalol Hydrochloride 120 MG Oral Tablet [Betapace]
9046031923427SBDSotalol Hydrochloride 80 MG Oral Tablet [Betapace]
9045791923424SCDSotalol Hydrochloride 160 MG Oral Tablet
9045671923422SCDSotalol Hydrochloride 120 MG Oral Tablet
9046011923426SCDSotalol Hydrochloride 80 MG Oral Tablet

The old and new RXCUIs can be found in the RXNCUI file along with the cardinality indicating the number of RXCUIs in which the original RXCUI was moved or split.

Data Counts

Term Type or AttributeNumber
Active GPCKs375
Active BPCKs444
Active SCDs18611
Active SBDs10466
Active RXNORM MINs3941
Active RXNORM INs11392
Active RXNORM PINs2669
Active RXNORM BNs6115
Active RXNORM DFs116
  
Obsolete GPCKs157
Obsolete BPCKs132
Obsolete SCDs16417
Obsolete SBDs10404
Obsolete RXNORM MINs0
Obsolete RXNORM INs0
Obsolete RXNORM PINs0
Obsolete RXNORM BNs9862
Obsolete RXNORM DFs59
Editor-suppressed SCDs1675
Editor-suppressed SBDs1348
SAB=RXNORM NDCs230091
Distinct SAB=RXNORM NDCs230091