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Unified Medical Language System® (UMLS®)

RxNorm Release Notes

May Release - 5/06/2019

This release of RxNorm is consistent with the 2019AA UMLS Metathesaurus release. For additional information about RxNorm releases, including scripts for loading the RxNorm data into Oracle and MySQL databases, read the RxNorm Technical Documentation.

Sources

The following sources with version names in bold have been updated since the previous RxNorm release:

Source NameSABVersion
Vaccines Administered CVX CVX_2019_03_21
DrugBank DRUGBANK DRUGBANK5.0_2019_04_04
Gold Standard Drug Database GS GS_2019_03_29
Multum MediSource Lexicon MMSL MMSL_2019_04_01
Micromedex RED BOOK MMX MMX_2019_04_01
Medical Subject Headings (MeSH) MSH MSH2019_2019_01_07
FDA Structured Product Labels MTHSPL MTHSPL_2019_04_29
FDB MedKnowledge (formerly NDDF Plus) NDDF NDDF_2019_03_27
RxNorm normalized names and codes RXNORM RXNORM_19AA_190506F
Veterans Health Administration National Drug File VANDF VANDF_2019_03_31


The following sources have not been updated since the previous RxNorm release:

Source NameSABVersion
Anatomical Therapeutic Chemical Classification System ATC ATC_2019
CMS Formulary Reference File MTHCMSFRF MTHCMSFRF_2014
US Edition of SNOMED CT (drug information) SNOMEDCT_US SNOMEDCT_US_2019_01_31
USP Compendial Nomenclature USP USP_2018_12_10

*Reminder: As of October 2017, Medi-Span data will not be included in the RxNorm or UMLS releases. If you have questions about Medi-Span, please contact: medispan-support@wolterskluwer.com.

Data Changes

Qualitative Distinction
Qualitative Distinction modifiers allow flexibility in the RxNorm model to create new RXCUIs as needed. See the RxNorm Technical Documentation for more information about Qualitative Distinctions (QDs), which were first released in the August 2016 monthly release.

Here are the new concepts with QDs in the May 2019 release:

RXCUITTYString
2123111SCDNDA020503 200 ACTUAT Albuterol 0.09 MG/ACTUAT Metered Dose Inhaler
746763SBDNDA020503 200 ACTUAT Albuterol 0.09 MG/ACTUAT Metered Dose Inhaler [Proventil]
2123076SCDNDA020983 200 ACTUAT Albuterol 0.09 MG/ACTUAT Metered Dose Inhaler
859088SBDNDA020983 200 ACTUAT Albuterol 0.09 MG/ACTUAT Metered Dose Inhaler [Ventolin]
801092SCDNDA020983 60 ACTUAT Albuterol 0.09 MG/ACTUAT Metered Dose Inhaler
801095SBDNDA020983 60 ACTUAT Albuterol 0.09 MG/ACTUAT Metered Dose Inhaler [Ventolin]
2123072SCDNDA021457 200 ACTUAT Albuterol 0.09 MG/ACTUAT Metered Dose Inhaler
745752SBDNDA021457 200 ACTUAT Albuterol 0.09 MG/ACTUAT Metered Dose Inhaler [ProAir]
2123194SCDPulmonary Hypertension tadalafil 20 MG Oral Tablet
849866SBDPulmonary Hypertension tadalafil 20 MG Oral Tablet [Adcirca]
2110455SBDPulmonary Hypertension tadalafil 20 MG Oral Tablet [Alyq]

For each SCD or SBD with a QD, there is an associated attribute in RXNSAT with the attribute name (ATN) of 'RXN_QUALITATIVE_DISTINCTION'. The May release contains the following new attribute value (ATV) to match the QD strings found in the SCD and SBD normalized names:

  • NDA020503
  • NDA020983
  • NDA021457
  • Pulmonary Hypertension

NOTE: Multi-Ingredient Biologic Products and Naming in RxNorm
The National Library of Medicine (NLM) is aware that the biological product with multiple ingredients, Herceptin Hylecta, is currently misrepresented in RxNorm. The suffix is currently placed on one of the ingredients. However, after discussions with the U.S. Food & Drug Administration (FDA), NLM learned that the FDA’s intent is that the suffix is placed on the combination of ingredients.

  • Current RxNorm interpretation: trastuzumab and hyaluronidase-oysk
  • Correct interpretation: (trastuzumab and hyaluronidase)-oysk

The RxNorm team is collaborating with drug compendia, the National Council on Prescription Drug Programs (NCPDP), and the FDA to determine the best way to represent this information in electronic systems. Once a model is identified, NLM will work to modify the RxNorm data to represent this in a consistent manner with other drug information sources.

Data Counts

Term Type or AttributeNumber
Active GPCKs390
Active BPCKs487
Active SCDs18371
Active SBDs10342
Active RXNORM MINs3818
Active RXNORM INs12236
Active RXNORM PINs2853
Active RXNORM BNs5893
Active RXNORM DFs118
  
Obsolete GPCKs190
Obsolete BPCKs163
Obsolete SCDs16680
Obsolete SBDs10901
Obsolete RXNORM MINs0
Obsolete RXNORM INs0
Obsolete RXNORM PINs0
Obsolete RXNORM BNs6202
Obsolete RXNORM DFs60
Editor-suppressed SCDs1756
Editor-suppressed SBDs1454
SAB=RXNORM NDCs256089
Distinct SAB=RXNORM NDCs256089

Last Reviewed: May 6, 2019