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Unified Medical Language System® (UMLS®)

RxNorm Release Notes

June Release - 6/01/2020

This full release of RxNorm is consistent with the 2020AA UMLS Metathesaurus release. For additional information about RxNorm releases, including scripts for loading the RxNorm data into Oracle and MySQL databases, read the RxNorm Technical Documentation.


Sources

The following sources with version names in bold have been updated since the previous RxNorm release:

Source NameSABVersion
Vaccines Administered CVX CVX_2020_05_11
DrugBank DRUGBANK DRUGBANK5.0_2020_05_01
Gold Standard Drug Database GS GS_2020_05_14
Multum MediSource Lexicon MMSL MMSL_2020_05_01
Micromedex RED BOOK MMX MMX_2020_05_11
FDA Structured Product Labels MTHSPL MTHSPL_2020_05_21
FDB MedKnowledge (formerly NDDF Plus) NDDF NDDF_2020_05_13
RxNorm normalized names and codes RXNORM RXNORM_20AA_200601F
Veterans Health Administration National Drug File VANDF VANDF_2020_04_30


The following sources have not been updated since the previous RxNorm release:

Source NameSABVersion
Anatomical Therapeutic Chemical Classification System ATC ATC_2020
Medical Subject Headings (MeSH) MSH MSH2020_2020_01_15
CMS Formulary Reference File MTHCMSFRF MTHCMSFRF_2014
US Edition of SNOMED CT (drug information) SNOMEDCT_US SNOMEDCT_US_2020_01_31
USP Compendial Nomenclature USP USP_2020_02_06

*Reminder: As of October 2017, Medi-Span data will not be included in the RxNorm or UMLS releases. If you have questions about Medi-Span, please contact: medispan-support@wolterskluwer.com.


Data Changes

Investigational Drugs in RxNorm June 2020 Release and Use of "EUA" in Synonyms

In April 2020, RxNorm began including investigational drugs by adding the Semantic Clinical Drug (SCD): remdesivir 100 MG Injection. Two new investigational drug names have been included in the RxNorm June 2020 Release, the SCD: 20 ML remdesivir 5 MG/ML Injection and the Semantic Branded Drug (SBD): 100 ML propofol 20 MG/ML Injection [Propoven].

Also, the word "Investigational" was previously used in the Prescribable Name (PSN) and Synonym (SY) to indicate a drug's investigational status in the April and May RxNorm releases. Starting with the June 2020 release, "EUA" will replace "Investigational" in the PSNs and SYs for fully specified investigational drug names. Learn more about investigational drugs allowed under the FDA's Emergency Use Authorization (EUA).


The investigational drugs in RxNorm are:

  • SCD: 20 ML remdesivir 5 MG/ML Injection
    • RXCUI: 2367758
    • PSN: remdesivir 100 MG per 20 mL Injection (EUA)
  • SBD: 100 ML propofol 20 MG/ML Injection [Propoven]
    • RXCUI: 2370236
    • PSN: Propoven 2% in 100 mL Injection (EUA)
  • SCD: remdesivir 100 MG Injection
    • RXCUI: 2284960
    • PSN: remdesivir 100 MG Injection (EUA)

For more information about RxNorm's policy change to include investigational drugs, see the following NLM Technical Bulletin: https://www.nlm.nih.gov/pubs/techbull/ma20/ma20_rx_norm_investigational_drugs.html


Continued Reduction in Active National Drug Codes (NDCs)

Approximately 2,300 NDCs will no longer be active in the RxNorm dataset based on information from the FDA Structured Product Labeling (MTHSPL) data source. The SUPPRESS value for these NDCs in the RXNSAT.RRF file will change from SUPPRESS = 'N' in the RxNorm May 2020 release to SUPPRESS = 'Y' in the June 2020 release.


Notice of Upcoming Data Changes

As a courtesy to users, this section provides advance notice of possible upcoming RxNorm data changes. More information about each change will be provided or repeated in the future. Please note that planned data changes and timelines may change if issues arise.

  • MTHSPL National Health Related Item Code (NHRIC) values will be distinguished from National Drug Code (NDC) values in the RxNorm July 2020 Monthly Release
    • Approximately 640 values will be impacted in the RXNSAT.RRF file
  • Deleting UMLS Metathesaurus UMLSAUI and UMLSCUI in the RxNorm November 2020 Monthly Release
    • The Unified Medical Language System (UMLS) atom unique identifier (AUI) and concept unique identifier (CUI) will no longer exist in RxNorm beginning with the November 2020 release. In other words, the UMLSAUI and UMLSCUI attributes will be deleted from the RxNorm terminology in the RXNSAT.RRF file. Users can obtain the UMLSAUI and UMLSCUI directly from the UMLS Metathesaurus if needed.


Data Counts

Term Type or AttributeNumber
Active GPCKs437
Active BPCKs512
Active SCDs17361
Active SBDs9936
Active RXNORM MINs3737
Active RXNORM INs12667
Active RXNORM PINs2979
Active RXNORM BNs5567
Active RXNORM DFs121
  
Obsolete GPCKs217
Obsolete BPCKs197
Obsolete SCDs17526
Obsolete SBDs11212
Obsolete RXNORM MINs0
Obsolete RXNORM INs0
Obsolete RXNORM PINs0
Obsolete RXNORM BNs6383
Obsolete RXNORM DFs62
Editor-suppressed SCDs1766
Editor-suppressed SBDs1482
SAB=RXNORM NDCs248499
Distinct SAB=RXNORM NDCs248499

Last Reviewed: June 1, 2020