Skip Navigation Bar
NLM logo

Unified Medical Language System® (UMLS®)

RxNorm Release Notes

January Release - 01/04/2021

For additional information about RxNorm releases, including scripts for loading the RxNorm data into Oracle and MySQL databases, read the RxNorm Technical Documentation.


The following sources with version names in bold have been updated since the previous RxNorm release:

Source NameSABVersion
DrugBank DRUGBANK DRUGBANK5.0_2020_12_04
Gold Standard Drug Database GS GS_2020_12_15
Multum MediSource Lexicon MMSL MMSL_2020_12_01
Micromedex RED BOOK MMX MMX_2020_12_14
FDA Structured Product Labels MTHSPL MTHSPL_2020_12_28
FDB MedKnowledge (formerly NDDF Plus) NDDF NDDF_2020_12_16
RxNorm normalized names and codes RXNORM RXNORM_20AA_210104F
Veterans Health Administration National Drug File VANDF VANDF_2020_12_08

The following sources have not been updated since the previous RxNorm release:

Source NameSABVersion
Anatomical Therapeutic Chemical Classification System ATC ATC_2020
Vaccines Administered CVX CVX_2020_11_16
Medical Subject Headings (MeSH) MSH MSH2021_2020_07_16
CMS Formulary Reference File MTHCMSFRF MTHCMSFRF_2020
US Edition of SNOMED CT (drug information) SNOMEDCT_US SNOMEDCT_US_2020_07_31
USP Compendial Nomenclature USP USP_2020_02_06

*Reminder: As of October 2017, Medi-Span data will not be included in the RxNorm or UMLS releases. If you have questions about Medi-Span, please contact:

RxNorm Data Changes

REMINDER: COVID-19 Vaccines Added to RxNorm

Two COVID-19 vaccines were added to the RxNorm December 23, 2020 weekly releases and are included in the January 2021 monthly release.

Here is the new COVID-19 vaccine Semantic Clinical Drug (SCD) name, RxNorm Concept Unique Identifier (RXCUI), and National Drug Code (NDC) information:

First COVID-19 Vaccine SCD in RxNorm (Pfizer-BioNTech)

  • SCD: SARS-CoV-2 (COVID-19) vaccine, mRNA-BNT162b2 0.1 MG/ML Injectable Suspension
  • RXCUI: 2468235
  • NDC: 59267100001, 59267100002, 59267100003

Second COVID-19 Vaccine SCD in RxNorm (Moderna)

  • SCD: SARS-CoV-2 (COVID-19) vaccine, mRNA-1273 0.2 MG/ML Injectable Suspension
  • RXCUI: 2470234
  • NDC: 80777027310, 80777027399

Get more information about Emergency Use Authorization (EUA) from the FDA:

Get more information about RxNorm’s policy change on investigational drugs from NLM:


Inactive NDCs

Approximately 149 National Drug Codes (NDCs) will become inactive on RxNorm terminology normal forms as part of continuous data quality assurance. Users may see additional active content decrease over the next several months as the RxNorm Team continues to work with drug compendia to more correctly represent their obsolete and off-market data.

Related News

New Automated Download Steps

The UMLS Terminology Services (UTS) sign in process changed November 2020 rendering our previous terminology download automation scripts obsolete.

As a solution, NLM has developed several steps that should allow users to automate downloads with the new authentication system:  Apologies for any inconvenience and thank you for your patience.

RxNorm 2021 Release Schedule

The full RxNorm data set is released on the first Monday of each month. During months when the first Monday is a Federal holiday, RxNorm is released on the first Tuesday. The monthly release schedule for 2021 is:

January 4Monday
February 1Monday
March 1Monday
April 5Monday
May 3Monday
June 7Monday
July 6Tuesday
August 2Monday
September 7Tuesday
October 4Monday
November 1Monday
December 6Monday

Data Counts

Term Type or AttributeNumber
Active GPCKs429
Active BPCKs516
Active SCDs16891
Active SBDs9429
Active RXNORM MINs3735
Active RXNORM INs13136
Active RXNORM PINs3077
Active RXNORM BNs5132
Active RXNORM DFs121
Obsolete GPCKs231
Obsolete BPCKs198
Obsolete SCDs18253
Obsolete SBDs10733
Obsolete RXNORM MINs0
Obsolete RXNORM INs0
Obsolete RXNORM PINs0
Obsolete RXNORM BNs6103
Obsolete RXNORM DFs63
Editor-suppressed SCDs1795
Editor-suppressed SBDs1481
Distinct SAB=RXNORM NDCs250251

Last Reviewed: January 4, 2021