March Release - 03/01/2021
For additional information about RxNorm releases, including scripts for loading the RxNorm data into Oracle and MySQL databases, read the RxNorm Technical Documentation.
Sources
The following sources with version names in bold have been updated since the previous RxNorm release:
| Source Name | SAB | Version |
|---|---|---|
| Vaccines Administered | CVX | CVX_2021_01_29 |
| DrugBank | DRUGBANK | DRUGBANK5.0_2021_01_29 |
| Gold Standard Drug Database | GS | GS_2021_02_09 |
| Multum MediSource Lexicon | MMSL | MMSL_2021_02_01 |
| Micromedex RED BOOK | MMX | MMX_2021_02_08 |
| FDA Structured Product Labels | MTHSPL | MTHSPL_2021_02_19 |
| FDB MedKnowledge (formerly NDDF Plus) | NDDF | NDDF_2021_02_10 |
| RxNorm normalized names and codes | RXNORM | RXNORM_20AA_210301F |
| US Edition of SNOMED CT (drug information) | SNOMEDCT_US | SNOMEDCT_US_2021_01_31 |
| USP Compendial Nomenclature | USP | USP_2021_02_15 |
| Veterans Health Administration National Drug File | VANDF | VANDF_2021_01_29 |
The following sources have not been updated since the previous RxNorm release:
| Source Name | SAB | Version |
|---|---|---|
| Anatomical Therapeutic Chemical Classification System | ATC | ATC_2021 |
| Medical Subject Headings (MeSH) | MSH | MSH2021_2020_07_16 |
| CMS Formulary Reference File | MTHCMSFRF | MTHCMSFRF_2020 |
*Reminder: As of October 2017, Medi-Span data will not be included in the RxNorm or UMLS releases. If you have questions about Medi-Span, please contact: medispan-support@wolterskluwer.com.
RXNORM DATA CHANGES
REMINDER: Etesevimab included in RxNorm
Etesevimab, a drug allowed under the U.S. Food & Drug Administration Emergency Use Authorization (EUA), became available in the RxNorm February 24, 2021 weekly release and is in the RxNorm March 2021 monthly release also.
NOTE: Etesevimab is not authorized for use alone and must be administered with bamlanivimab.
Here is the etesevimab Semantic Clinical Drug (SCD) concept name, RxNorm Concept Unique Identifier (RXCUI), and National Drug Code (NDC):
- SCD: 20 ML etesevimab 35 MG/ML Injection
- RXCUI: 2477902
- NDC: 00002795001
New Casirivimab and Imdevimab Pack Concepts
Casirivimab and imdevimab are monoclonal antibodies that are to be administered together for the treatment of COVID-19. NDCs for packaged products of casirivimab and imdevimab together are now available in RxNorm.
Here are the new casirivimab and imdevimab Brand Name Pack (BPCK), Generic Pack (GPCK), RXCUIs, and NDCs:
- BPCK: {4 (2.5 ML casirivimab 120 MG/ML Injection) / 4 (2.5 ML imdevimab 120 MG/ML Injection) } Pack [REGEN-COV 4/4]
- RXCUI: 2479154
- NDC: 61755003608
- GPCK: {4 (2.5 ML casirivimab 120 MG/ML Injection) / 4 (2.5 ML imdevimab 120 MG/ML Injection) } Pack
- RXCUI: 2479153
- NDC: N/A
- BPCK: {1 (11.1 ML casirivimab 120 MG/ML Injection) / 1 (11.1 ML imdevimab 120 MG/ML Injection) } Pack [REGEN-COV 1/1]
- RXCUI: 2479150
- NDC: 61755003502
- GPCK: {1 (11.1 ML casirivimab 120 MG/ML Injection) / 1 (11.1 ML imdevimab 120 MG/ML Injection) } Pack
- RXCUI: 2479149
- NDC: N/A
- BPCK: {1 (11.1 ML casirivimab 120 MG/ML Injection) / 4 (2.5 ML imdevimab 120 MG/ML Injection) } Pack [REGEN-COV 1/4]
- RXCUI: 2479159
- NDC: 61755003708
- GPCK: {1 (11.1 ML casirivimab 120 MG/ML Injection) / 4 (2.5 ML imdevimab 120 MG/ML Injection) } Pack
- RXCUI: 2479158
- NDC: N/A
- BPCK: {1 (11.1 ML imdevimab 120 MG/ML Injection) / 4 (2.5 ML casirivimab 120 MG/ML Injection) } Pack [REGEN-COV 4/1]
- RXCUI: 2479156
- NDC: 61755003805
- GPCK: {1 (11.1 ML imdevimab 120 MG/ML Injection) / 4 (2.5 ML casirivimab 120 MG/ML Injection) } Pack
- RXCUI: 2479155
- NDC: N/A
Get more information about Emergency Use Authorization (EUA) from the FDA:
Get more information about RxNorm's policy change on investigational drugs from NLM:
Continued Reduction in Active National Drug Codes (NDCs)
As part of data quality improvement, the number of live NDCs will decrease by approximately 3,500 NDCs in the March 2021 release. The SUPPRESS value for many of these NDCs in the RXNSAT.RRF file will change from SUPPRESS = "N" to SUPPRESS = "Y" compared to last month's release. Most of these NDCs represent allergenic extract concepts that will become obsolete.
RELATED NEWS
In response to the COVID-19 pandemic, a web page listing COVID-19 Vaccines and Medications in RxNorm is now available. The page will be updated as new COVID-19 related concepts are released in RxNorm.
Data Counts
| Term Type or Attribute | Number |
|---|---|
| Active GPCKs | 436 |
| Active BPCKs | 520 |
| Active SCDs | 16429 |
| Active SBDs | 9445 |
| Active RXNORM MINs | 3737 |
| Active RXNORM INs | 13206 |
| Active RXNORM PINs | 3098 |
| Active RXNORM BNs | 5143 |
| Active RXNORM DFs | 121 |
| Obsolete GPCKs | 234 |
| Obsolete BPCKs | 202 |
| Obsolete SCDs | 18792 |
| Obsolete SBDs | 10746 |
| Obsolete RXNORM MINs | 0 |
| Obsolete RXNORM INs | 0 |
| Obsolete RXNORM PINs | 0 |
| Obsolete RXNORM BNs | 6096 |
| Obsolete RXNORM DFs | 63 |
| Editor-suppressed SCDs | 1806 |
| Editor-suppressed SBDs | 1487 |
| SAB=RXNORM NDCs | 247545 |
| Distinct SAB=RXNORM NDCs | 247545 |
Last Reviewed: March 1, 2021