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Unified Medical Language System® (UMLS®)

RxNorm Release Notes

March Release - 03/01/2021

For additional information about RxNorm releases, including scripts for loading the RxNorm data into Oracle and MySQL databases, read the RxNorm Technical Documentation.


Sources

The following sources with version names in bold have been updated since the previous RxNorm release:

Source NameSABVersion
Vaccines Administered CVX CVX_2021_01_29
DrugBank DRUGBANK DRUGBANK5.0_2021_01_29
Gold Standard Drug Database GS GS_2021_02_09
Multum MediSource Lexicon MMSL MMSL_2021_02_01
Micromedex RED BOOK MMX MMX_2021_02_08
FDA Structured Product Labels MTHSPL MTHSPL_2021_02_19
FDB MedKnowledge (formerly NDDF Plus) NDDF NDDF_2021_02_10
RxNorm normalized names and codes RXNORM RXNORM_20AA_210301F
US Edition of SNOMED CT (drug information) SNOMEDCT_US SNOMEDCT_US_2021_01_31
USP Compendial Nomenclature USP USP_2021_02_15
Veterans Health Administration National Drug File VANDF VANDF_2021_01_29


The following sources have not been updated since the previous RxNorm release:

Source NameSABVersion
Anatomical Therapeutic Chemical Classification System ATC ATC_2021
Medical Subject Headings (MeSH) MSH MSH2021_2020_07_16
CMS Formulary Reference File MTHCMSFRF MTHCMSFRF_2020

*Reminder: As of October 2017, Medi-Span data will not be included in the RxNorm or UMLS releases. If you have questions about Medi-Span, please contact: medispan-support@wolterskluwer.com.


RXNORM DATA CHANGES

REMINDER: Etesevimab included in RxNorm

Etesevimab, a drug allowed under the U.S. Food & Drug Administration Emergency Use Authorization (EUA), became available in the RxNorm February 24, 2021 weekly release and is in the RxNorm March 2021 monthly release also.

NOTE: Etesevimab is not authorized for use alone and must be administered with bamlanivimab.

Here is the etesevimab Semantic Clinical Drug (SCD) concept name, RxNorm Concept Unique Identifier (RXCUI), and National Drug Code (NDC):

  • SCD: 20 ML etesevimab 35 MG/ML Injection
  • RXCUI: 2477902
  • NDC: 00002795001

New Casirivimab and Imdevimab Pack Concepts

Casirivimab and imdevimab are monoclonal antibodies that are to be administered together for the treatment of COVID-19. NDCs for packaged products of casirivimab and imdevimab together are now available in RxNorm.

Here are the new casirivimab and imdevimab Brand Name Pack (BPCK), Generic Pack (GPCK), RXCUIs, and NDCs:

  • BPCK: {4 (2.5 ML casirivimab 120 MG/ML Injection) / 4 (2.5 ML imdevimab 120 MG/ML Injection) } Pack [REGEN-COV 4/4]
  • RXCUI: 2479154
  • NDC: 61755003608
  • GPCK: {4 (2.5 ML casirivimab 120 MG/ML Injection) / 4 (2.5 ML imdevimab 120 MG/ML Injection) } Pack
  • RXCUI: 2479153
  • NDC: N/A
  • BPCK: {1 (11.1 ML casirivimab 120 MG/ML Injection) / 1 (11.1 ML imdevimab 120 MG/ML Injection) } Pack [REGEN-COV 1/1] 
  • RXCUI: 2479150
  • NDC: 61755003502
  • GPCK: {1 (11.1 ML casirivimab 120 MG/ML Injection) / 1 (11.1 ML imdevimab 120 MG/ML Injection) } Pack
  • RXCUI: 2479149
  • NDC: N/A
  • BPCK: {1 (11.1 ML casirivimab 120 MG/ML Injection) / 4 (2.5 ML imdevimab 120 MG/ML Injection) } Pack [REGEN-COV 1/4]
  • RXCUI: 2479159
  • NDC: 61755003708
  • GPCK: {1 (11.1 ML casirivimab 120 MG/ML Injection) / 4 (2.5 ML imdevimab 120 MG/ML Injection) } Pack
  • RXCUI: 2479158
  • NDC: N/A
  • BPCK: {1 (11.1 ML imdevimab 120 MG/ML Injection) / 4 (2.5 ML casirivimab 120 MG/ML Injection) } Pack [REGEN-COV 4/1]  
  • RXCUI: 2479156
  • NDC: 61755003805
  • GPCK: {1 (11.1 ML imdevimab 120 MG/ML Injection) / 4 (2.5 ML casirivimab 120 MG/ML Injection) } Pack
  • RXCUI: 2479155
  • NDC: N/A

Get more information about Emergency Use Authorization (EUA) from the FDA:

Get more information about RxNorm's policy change on investigational drugs from NLM:


Continued Reduction in Active National Drug Codes (NDCs)

As part of data quality improvement, the number of live NDCs will decrease by approximately 3,500 NDCs in the March 2021 release. The SUPPRESS value for many of these NDCs in the RXNSAT.RRF file will change from SUPPRESS = "N" to SUPPRESS = "Y" compared to last month's release. Most of these NDCs represent allergenic extract concepts that will become obsolete.


RELATED NEWS

In response to the COVID-19 pandemic, a web page listing COVID-19 Vaccines and Medications in RxNorm is now available. The page will be updated as new COVID-19 related concepts are released in RxNorm.


Data Counts

Term Type or AttributeNumber
Active GPCKs436
Active BPCKs520
Active SCDs16429
Active SBDs9445
Active RXNORM MINs3737
Active RXNORM INs13206
Active RXNORM PINs3098
Active RXNORM BNs5143
Active RXNORM DFs121
  
Obsolete GPCKs234
Obsolete BPCKs202
Obsolete SCDs18792
Obsolete SBDs10746
Obsolete RXNORM MINs0
Obsolete RXNORM INs0
Obsolete RXNORM PINs0
Obsolete RXNORM BNs6096
Obsolete RXNORM DFs63
Editor-suppressed SCDs1806
Editor-suppressed SBDs1487
SAB=RXNORM NDCs247545
Distinct SAB=RXNORM NDCs247545

Last Reviewed: March 1, 2021