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Unified Medical Language System® (UMLS®)

RxNorm Release Notes

July Release - 07/06/2021

For additional information about RxNorm releases, including scripts for loading the RxNorm data into Oracle and MySQL databases, read the RxNorm Technical Documentation.


The following sources with version names in bold have been updated since the previous RxNorm release:

Source NameSABVersion
DrugBank DRUGBANK DRUGBANK5.0_2021_06_04
Gold Standard Drug Database GS GS_2021_06_10
Multum MediSource Lexicon MMSL MMSL_2021_06_01
Micromedex RED BOOK MMX MMX_2021_06_07
FDA Structured Product Labels MTHSPL MTHSPL_2021_06_28
FDB MedKnowledge (formerly NDDF Plus) NDDF NDDF_2021_06_16
RxNorm normalized names and codes RXNORM RXNORM_20AA_210706F
USP Compendial Nomenclature USP USP_2021_06_15
Veterans Health Administration National Drug File VANDF VANDF_2021_05_31

The following sources have not been updated since the previous RxNorm release:

Source NameSABVersion
Anatomical Therapeutic Chemical Classification System ATC ATC_2021
Vaccines Administered CVX CVX_2021_05_20
Medical Subject Headings (MeSH) MSH MSH2021_2021_01_25
CMS Formulary Reference File MTHCMSFRF MTHCMSFRF_2020
US Edition of SNOMED CT (drug information) SNOMEDCT_US SNOMEDCT_US_2021_01_31

*Reminder: As of October 2017, Medi-Span data will not be included in the RxNorm or UMLS releases. If you have questions about Medi-Span, please contact:


Two New COVID-19-Related Concepts Added

First, sotrovimab, a drug allowed under the U.S. Food & Drug Administration Emergency Use Authorization (EUA), became available in the RxNorm June 9, 2021 weekly release and is in the RxNorm July 2021 monthly release also.

Here is the sotrovimab Semantic Clinical Drug (SCD) concept name, RxNorm Concept Unique Identifier (RXCUI), and National Drug Code (NDC):

  • SCD: 8 ML sotrovimab 62.5 MG/ML Injection
  • RXCUI: 2550903
  • NDC: 00173090186

Second, a new concept for a propofol lipid emulsion product is also included. This product is an investigational infusion to maintain sedation in patients 16 or older who require mechanical ventilation in an Intensive Care Unit (ICU) setting during the 2019 coronavirus disease (COVID-19) pandemic.

Here is the new propofol lipid emulsion SCD name, RXCUI, and NDC:

  • SCD: 100 ML propofol lipid emulsion 10 MG/ML Injection
  • RXCUI: 2559909
  • NDC: 00264485001

Notice of Upcoming Data Changes

As a courtesy to users, this section provides advance notice of possible upcoming RxNorm data changes. More information about each change will be provided or repeated in the future. Please note that planned data changes and timelines may change if issues arise.

REMINDER: Basis of Strength (BoSS) Attributes Changing Fall 2021

Several BoSS attributes are planned to change this fall. A specific month is not available, but is likely to occur September 2021 at the earliest. Below are more details. Please plan accordingly.

  • BoSS Attributes Moving:
    • RXN_BOSS_AI, RXN_BOSS_AM, and RXN_BOSS_FROM attributes will change from being present on an SCDC to an SCD, likewise on an SBDC to an SBD
    • Please note that this change will happen over time. For example, some products, such as medical gases and multi-ingredient products including multivitamins, will be addressed at a later time.
  • BoSS Attribute Name Changes:
    • RXN_BOSS_AI will be renamed RXN_AI
    • RXN_BOSS_AM will be renamed RXN_AM

Data Counts

Term Type or AttributeNumber
Active GPCKs449
Active BPCKs533
Active SCDs17072
Active SBDs9501
Active RXNORM MINs3746
Active RXNORM INs13440
Active RXNORM PINs3123
Active RXNORM BNs5162
Active RXNORM DFs121
Obsolete GPCKs239
Obsolete BPCKs205
Obsolete SCDs18331
Obsolete SBDs10811
Obsolete RXNORM MINs0
Obsolete RXNORM INs0
Obsolete RXNORM PINs0
Obsolete RXNORM BNs6110
Obsolete RXNORM DFs63
Editor-suppressed SCDs1834
Editor-suppressed SBDs1513
Distinct SAB=RXNORM NDCs255970

Last Reviewed: July 6, 2021