Skip Navigation Bar
NLM logo

Unified Medical Language System® (UMLS®)

RxNorm Release Notes

October Release - 10/04/2021

For additional information about RxNorm releases, including scripts for loading the RxNorm data into Oracle and MySQL databases, read the RxNorm Technical Documentation.


The following sources with version names in bold have been updated since the previous RxNorm release:

Source NameSABVersion
Vaccines Administered CVX CVX_2021_09_15
DrugBank DRUGBANK DRUGBANK5.0_2021_09_03
Gold Standard Drug Database GS GS_2021_09_08
Multum MediSource Lexicon MMSL MMSL_2021_09_01
Micromedex RED BOOK MMX MMX_2021_09_12
FDA Structured Product Labels MTHSPL MTHSPL_2021_09_24
FDB MedKnowledge (formerly NDDF Plus) NDDF NDDF_2021_09_08
RxNorm normalized names and codes RXNORM RXNORM_20AA_211004F
Veterans Health Administration National Drug File VANDF VANDF_2021_08_31

The following sources have not been updated since the previous RxNorm release:

Source NameSABVersion
Anatomical Therapeutic Chemical Classification System ATC ATC_2021
Medical Subject Headings (MeSH) MSH MSH2021_2021_01_25
CMS Formulary Reference File MTHCMSFRF MTHCMSFRF_2020
US Edition of SNOMED CT (drug information) SNOMEDCT_US SNOMEDCT_US_2021_07_31
USP Compendial Nomenclature USP USP_2021_07_15

*Reminder: As of October 2017, Medi-Span data will not be included in the RxNorm or UMLS releases. If you have questions about Medi-Span, please contact:


No major changes


FDA Approves First COVID-19 Vaccine

Pfizer received FDA biologics license application (BLA) approval on August 23, 2021 for its COVID-19 vaccine for use in individuals 16 and older, which will now be marketed as COMIRNATY. At that time, the FDA published a BLA package insert that included the approved new COVID-19 vaccine tradename COMIRNATY and listed 2 new NDCs (0069-1000-03, 0069-1000-02) and images of labels with the new tradename.

At present, Pfizer does not plan to produce any product with these new NDCs and labels over the next few months while the emergency use authorized (EUA) product is still available and being made available for U.S. distribution. As such, the CDC, AMA, and drug compendia may not publish these new codes until Pfizer has determined when the product will be produced with the BLA labels.

Data Counts

Term Type or AttributeNumber
Active GPCKs454
Active BPCKs532
Active SCDs17155
Active SBDs9514
Active RXNORM MINs3764
Active RXNORM INs13534
Active RXNORM PINs3144
Active RXNORM BNs5162
Active RXNORM DFs121
Obsolete GPCKs242
Obsolete BPCKs208
Obsolete SCDs18444
Obsolete SBDs10903
Obsolete RXNORM MINs0
Obsolete RXNORM INs0
Obsolete RXNORM PINs0
Obsolete RXNORM BNs6148
Obsolete RXNORM DFs63
Editor-suppressed SCDs1846
Editor-suppressed SBDs1522
Distinct SAB=RXNORM NDCs256836

Last Reviewed: October 4, 2021