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Unified Medical Language System® (UMLS®)

RxNorm Release Notes

November Release - 11/1/2021

For additional information about RxNorm releases, including scripts for loading the RxNorm data into Oracle and MySQL databases, read the RxNorm Technical Documentation.


The following sources with version names in bold have been updated since the previous RxNorm release:

Source NameSABVersion
DrugBank DRUGBANK DRUGBANK5.0_2021_10_01
Gold Standard Drug Database GS GS_2021_10_07
Multum MediSource Lexicon MMSL MMSL_2021_10_01
Micromedex RED BOOK MMX MMX_2021_10_11
Medical Subject Headings (MeSH) MSH MSH2022_2021_07_20
FDA Structured Product Labels MTHSPL MTHSPL_2021_10_22
FDB MedKnowledge (formerly NDDF Plus) NDDF NDDF_2021_10_06
RxNorm normalized names and codes RXNORM RXNORM_20AA_211101F
Veterans Health Administration National Drug File VANDF VANDF_2021_09_30

The following sources have not been updated since the previous RxNorm release:

Source NameSABVersion
Anatomical Therapeutic Chemical Classification System ATC ATC_2021
Vaccines Administered CVX CVX_2021_09_15
CMS Formulary Reference File MTHCMSFRF MTHCMSFRF_2020
US Edition of SNOMED CT (drug information) SNOMEDCT_US SNOMEDCT_US_2021_07_31
USP Compendial Nomenclature USP USP_2021_07_15

*Reminder: As of October 2017, Medi-Span data will not be included in the RxNorm or UMLS releases. If you have questions about Medi-Span, please contact:


New Concept for Restasis Single-Use Vials

Restasis is an eye medication available in multi-dose bottles and single-dose vials. RXCUI 402092 represented both the multi-dose and the single-dose Restasis products. However, the single-use product will be split into a distinct RxNorm concept (RXCUI 2572293) starting with the November 2021 release. The existing concept RXCUI 402092 will represent the multi-dose product.

The new Restasis single-use and related generic concepts are:

2572293SBD0.4 ML cyclosporine 0.5 MG/ML Ophthalmic Suspension [Restasis]
2572292SCD0.4 ML cyclosporine 0.5 MG/ML Ophthalmic Suspension

The Restasis multi-dose and related generic concepts are:

402092SBDcyclosporine 0.5 MG/ML Ophthalmic Suspension [Restasis]
351291SCDcyclosporine 0.5 MG/ML Ophthalmic Suspension

Data Counts

Term Type or AttributeNumber
Active GPCKs454
Active BPCKs529
Active SCDs17169
Active SBDs9512
Active RXNORM MINs3764
Active RXNORM INs13560
Active RXNORM PINs3152
Active RXNORM BNs5163
Active RXNORM DFs121
Obsolete GPCKs243
Obsolete BPCKs211
Obsolete SCDs18447
Obsolete SBDs10917
Obsolete RXNORM MINs0
Obsolete RXNORM INs0
Obsolete RXNORM PINs0
Obsolete RXNORM BNs6155
Obsolete RXNORM DFs63
Editor-suppressed SCDs1849
Editor-suppressed SBDs1525
Distinct SAB=RXNORM NDCs257480

Last Reviewed: November 1, 2021