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Unified Medical Language System® (UMLS®)

RxNorm Release Notes

December Release - 12/6/2021

For additional information about RxNorm releases, including scripts for loading the RxNorm data into Oracle and MySQL databases, read the RxNorm Technical Documentation.


The following sources with version names in bold have been updated since the previous RxNorm release:

Source NameSABVersion
Vaccines Administered CVX CVX_2021_11_19
DrugBank DRUGBANK DRUGBANK5.0_2021_11_01
Gold Standard Drug Database GS GS_2021_11_04
Multum MediSource Lexicon MMSL MMSL_2021_11_01
Micromedex RED BOOK MMX MMX_2021_11_01
FDA Structured Product Labels MTHSPL MTHSPL_2021_11_26
FDB MedKnowledge (formerly NDDF Plus) NDDF NDDF_2021_11_03
RxNorm normalized names and codes RXNORM RXNORM_20AA_211206F
Veterans Health Administration National Drug File VANDF VANDF_2021_10_31

The following sources have not been updated since the previous RxNorm release:

Source NameSABVersion
Anatomical Therapeutic Chemical Classification System ATC ATC_2021
CMS Formulary Reference File MTHCMSFRF MTHCMSFRF_2020
Medical Subject Headings (MeSH) MSH MSH2022_2021_07_20
US Edition of SNOMED CT (drug information) SNOMEDCT_US SNOMEDCT_US_2021_07_31
USP Compendial Nomenclature USP USP_2021_07_15

*Reminder: As of October 2017, Medi-Span data will not be included in the RxNorm or UMLS releases. If you have questions about Medi-Span, please contact:


Added Pfizer-BioNTech COVID-19 Vaccine for Children

The Pfizer-BioNTech COVID-19 Vaccine for children 5 through 11 years of age was recently authorized for emergency use by the U.S. Food and Drug Administration and is included in the RxNorm December 2021 monthly releases.

Here is the new COVID-19 vaccine concept information in RxNorm:

2583743SARS-CoV-2 (COVID-19) vaccine, mRNA-BNT162b2 0.05 MG/ML Injectable Suspension

Get more information about Emergency Use Authorization (EUA) from the FDA
Get more information about RxNorm's policy change on investigational drugs from NLM

Data Counts

Term Type or AttributeNumber
Active GPCKs454
Active BPCKs529
Active SCDs17149
Active SBDs9526
Active RXNORM MINs3765
Active RXNORM INs13546
Active RXNORM PINs3210
Active RXNORM BNs5168
Active RXNORM DFs121
Obsolete GPCKs243
Obsolete BPCKs211
Obsolete SCDs18504
Obsolete SBDs10928
Obsolete RXNORM MINs0
Obsolete RXNORM INs0
Obsolete RXNORM PINs0
Obsolete RXNORM BNs6159
Obsolete RXNORM DFs63
Editor-suppressed SCDs1851
Editor-suppressed SBDs1529
Distinct SAB=RXNORM NDCs258643

Last Reviewed: December 6, 2021