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Unified Medical Language System® (UMLS®)

RxNorm Release Notes

June Release - 06/06/2022

For additional information about RxNorm releases, including scripts for loading the RxNorm data into Oracle and MySQL databases, read the RxNorm Technical Documentation.


The following sources with version names in bold have been updated since the previous RxNorm release:

Source NameSABVersion
DrugBank DRUGBANK DRUGBANK5.0_2022_05_05
Gold Standard Drug Database GS GS_2022_05_11
Multum MediSource Lexicon MMSL MMSL_2022_05_01
Micromedex RED BOOK MMX MMX_2022_05_09
FDA Structured Product Labels MTHSPL MTHSPL_2022_05_26
FDB MedKnowledge (formerly NDDF Plus) NDDF NDDF_2022_05_11
RxNorm normalized names and codes RXNORM RXNORM_20AA_220606F
Veterans Health Administration National Drug File VANDF VANDF_2022_04_29

The following sources have not been updated since the previous RxNorm release:

Source NameSABVersion
Anatomical Therapeutic Chemical Classification System ATC ATC_2022
Vaccines Administered CVX CVX_2022_04_14
Medical Subject Headings (MeSH) MSH MSH2022_2021_07_20
CMS Formulary Reference File MTHCMSFRF MTHCMSFRF_2020
US Edition of SNOMED CT (drug information) SNOMEDCT_US SNOMEDCT_US_2022_01_31
USP Compendial Nomenclature USP USP_2022_2_15

*Reminder: As of October 2017, Medi-Span data will not be included in the RxNorm or UMLS releases. If you have questions about Medi-Span, please contact:

RxNorm Data Changes

Sotrovimab Status Change

The U.S. Food and Drug Administration determined that sotrovimab is no longer authorized to treat COVID-19 in any U.S. region earlier this year. The RxNorm data reflects this by the lack of both the Attribute Name (ATN) “RXN_HUMAN_DRUG” and a corresponding Attribute Value (ATV) for RxNorm Concept Unique Identifier (RXCUI) 2550903 with string “8 ML sotrovimab 62.5 MG/ML Injection”. The RxNorm terminology (SAB=RXNORM) National Drug Code is also absent, and the “(EUA)” in the Prescribable Name (PSN) has been deleted.

Get more information about sotrovimab from the FDA:

New Spikevax COVID-19 Vaccine Concept Added

The Moderna COVID-19 vaccine will be marketed as Spikevax. To reflect this change, a Semantic Branded Drug (SBD) concept for Spikevax will be in the RxNorm June monthly release.

Here is the new Spikevax COVID-19 vaccine concept in RxNorm:

2601552SBDSARS-CoV-2 (COVID-19) vaccine, mRNA-1273 0.2 MG/ML Injectable Suspension [Spikevax]

Get more information about Spikevax from the FDA:

Data Counts

Term Type or AttributeNumber
Active GPCKs463
Active BPCKs536
Active SCDs17158
Active SBDs9464
Active RXNORM MINs3773
Active RXNORM INs13788
Active RXNORM PINs3268
Active RXNORM BNs5101
Active RXNORM DFs121
Obsolete GPCKs249
Obsolete BPCKs218
Obsolete SCDs18715
Obsolete SBDs11154
Obsolete RXNORM MINs0
Obsolete RXNORM INs0
Obsolete RXNORM PINs0
Obsolete RXNORM BNs6292
Obsolete RXNORM DFs63
Editor-suppressed SCDs1892
Editor-suppressed SBDs1561
Distinct SAB=RXNORM NDCs242798

Last Reviewed: June 6, 2022