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RxNorm Release Notes

September Release - 09/06/2022

For additional information about RxNorm releases, including scripts for loading the RxNorm data into Oracle and MySQL databases, read the RxNorm Technical Documentation.

Sources

The following sources with version names in bold have been updated since the previous RxNorm release:

Source NameSABVersion
DrugBank DRUGBANK DRUGBANK5.0_2022_08_01
Gold Standard Drug Database GS GS_2022_08_05
Multum MediSource Lexicon MMSL MMSL_2022_08_01
Micromedex RED BOOK MMX MMX_2022_08_08
FDA Structured Product Labels MTHSPL MTHSPL_2022_08_26
FDB MedKnowledge (formerly NDDF Plus) NDDF NDDF_2022_08_10
RxNorm normalized names and codes RXNORM RXNORM_20AA_220906F
US Edition of SNOMED CT (drug information) SNOMEDCT_US SNOMEDCT_US_2022_07_31
USP Compendial Nomenclature USP USP_2022_8_12
Veterans Health Administration National Drug File VANDF VANDF_2022_07_29


The following sources have not been updated since the previous RxNorm release:

Source NameSABVersion
Anatomical Therapeutic Chemical Classification System ATC ATC_2022
Vaccines Administered CVX CVX_2022_06_23
Medical Subject Headings (MeSH) MSH MSH2022_2021_07_20
CMS Formulary Reference File MTHCMSFRF MTHCMSFRF_2020

*Reminder: As of October 2017, Medi-Span data will not be included in the RxNorm or UMLS releases. If you have questions about Medi-Span, please contact: medispan-support@wolterskluwer.com.


RxNorm Data Changes


Paxlovid Pack PSN Synonyms Updated

Paxlovid is an investigational drug indicated for the treatment of certain cases of COVID-19 under a U.S. Food and Drug Administration (FDA) Emergency Use Authorization (EUA). The RxNorm team was made aware of concerns regarding dosing errors related to Paxlovid. One discussion of possible errors can be found here: Numerous Wrong Dose Errors with PAXLOVID.

RxNorm Prescribable Name (PSN) synonyms for Paxlovid brand name and generic packs were updated to help clearly identify to prescribers which pack is being prescribed. For example, one of the Paxlovid brand name pack PSNs now includes the word “Renal”.

Here are the previous PSNs for Paxlovid-related brand name and generic pack concepts in the RxNorm terminology:

RXCUI Term Type
(TTY)
STR
2587899 PSN PAXLOVID 300 MG / 100 MG 5-Day Pack (EUA)
2599543 PSN PAXLOVID 150 MG /100 MG Dose Pack (EUA)
2587898 PSN nirmatrelvir 150 MG Oral Tablet (20) / ritonavir 100 MG Oral Tablet (10) 5 Day Pack (EUA)
2599542 PSN nirmatrelvir 150 MG Oral Tablet (10) / ritonavir 100 MG Oral Tablet (10) 150 MG /100 MG Dose Pack (EUA)


Here are the updated PSNs for Paxlovid-related brand name and generic pack concepts in the RxNorm terminology:

RXCUI Term Type
(TTY)
STR
2587899 PSN PAXLOVID 300 MG ; 100 MG 5-Day Pack (EUA)
2599543 PSN PAXLOVID 150 MG ; 100 MG Dose Pack (EUA), Renal
2587898 PSN nirmatrelvir 300 MG ; ritonavir 100 MG Daily Dose Pack (EUA)
2599542 PSN nirmatrelvir 150 MG ; ritonavir 100 MG Daily Dose Pack (EUA), Renal


Data Counts

Term Type or AttributeNumber
Active GPCKs474
Active BPCKs543
Active SCDs17226
Active SBDs9424
Active RXNORM MINs3776
Active RXNORM INs13856
Active RXNORM PINs3295
Active RXNORM BNs5065
Active RXNORM DFs122
  
Obsolete GPCKs252
Obsolete BPCKs219
Obsolete SCDs18759
Obsolete SBDs11264
Obsolete RXNORM MINs0
Obsolete RXNORM INs0
Obsolete RXNORM PINs0
Obsolete RXNORM BNs6356
Obsolete RXNORM DFs63
Editor-suppressed SCDs1901
Editor-suppressed SBDs1569
SAB=RXNORM NDCs245331
Distinct SAB=RXNORM NDCs245331

Last Reviewed: September 6, 2022