July Release - 07/03/2023
For additional information about RxNorm releases, including scripts for loading the RxNorm data into Oracle and MySQL databases, read the RxNorm Technical Documentation.
Sources
The following sources with version names in bold have been updated since the previous RxNorm release:
| Source Name | Source Abbreviation (SAB) | Version |
|---|---|---|
| Vaccines Administered | CVX | CVX_2023_06_12 |
| DrugBank | DRUGBANK | DRUGBANK5.0_2023_06_09 |
| Gold Standard Drug Database | GS | GS_2023_06_08 |
| Multum MediSource Lexicon | MMSL | MMSL_2023_06_01 |
| Micromedex RED BOOK | MMX | MMX_2023_06_05 |
| FDA Structured Product Labels | MTHSPL | MTHSPL_2023_06_23 |
| FDB MedKnowledge (formerly NDDF Plus) | NDDF | NDDF_2023_06_07 |
| RxNorm normalized names and codes | RXNORM | RXNORM_20AA_230703F |
| Veterans Health Administration National Drug File | VANDF | VANDF_2023_05_31 |
The following sources have not been updated since the previous RxNorm release:
| Source Name | SAB | Version |
|---|---|---|
| Anatomical Therapeutic Chemical Classification System | ATC | ATC_2023_03_21 |
| Medical Subject Headings (MeSH) | MSH | MSH2023_2022_07_27 |
| CMS Formulary Reference File | MTHCMSFRF | MTHCMSFRF_2020 |
| US Edition of SNOMED CT (drug information) | SNOMEDCT_US | SNOMEDCT_US_2022_12_31 |
| USP Compendial Nomenclature | USP | USP_2023_05_08 |
*Reminder: As of October 2017, Medi-Span data will not be included in the RxNorm or UMLS releases. If you have questions about Medi-Span, please contact: medispan-support@wolterskluwer.com.
RxNorm Data Changes
New Dose Form: Ophthalmic Spray
RxNorm includes a new dose form: Ophthalmic Spray. This dose form is defined as a spray intended for use in the eye.
Here are the fully-specified product name concepts with the new dose form “Ophthalmic Spray” in the July 2023 release:
| RXCUI | Term Type (TTY) | String |
|---|---|---|
| 2638481 | SCD | phenylephrine hydrochloride 25 MG/ML / tropicamide 10 MG/ML Ophthalmic Spray |
| 2638486 | SBD | phenylephrine hydrochloride 25 MG/ML / tropicamide 10 MG/ML Ophthalmic Spray [Mydcombi] |
Pediatric and Adult Forms of Lupron Split
RxNorm includes a new Qualitative Distinction modifier: “Pediatric” that distinguishes the pediatric and adult forms of Lupron. Where necessary, existing RXCUIs were split to create new RXCUIs for the pediatric forms:
| Existing RXCUI (Adult form) | Term Type (TTY) | Existing String (Adult form) | New RXCUI (Pediatric form) | New String (Pediatric form) |
|---|---|---|---|---|
| 1115462 | SCD | 1 ML leuprolide acetate 7.5 MG/ML Prefilled Syringe | 2639742 | Pediatric 1 ML leuprolide acetate 7.5 MG/ML Prefilled Syringe |
| 1115464 | SBD | 1 ML leuprolide acetate 7.5 MG/ML Prefilled Syringe [Lupron] | 2639743 | Pediatric 1 ML leuprolide acetate 7.5 MG/ML Prefilled Syringe [Lupron] |
| 1115257 | SCD | 1.5 ML leuprolide acetate 30 MG/ML Prefilled Syringe | 2639668 | Pediatric 1.5 ML leuprolide acetate 30 MG/ML Prefilled Syringe |
| 1115259 | SBD | 1.5 ML leuprolide acetate 30 MG/ML Prefilled Syringe [Lupron] | 2639669 | Pediatric 1.5 ML leuprolide acetate 30 MG/ML Prefilled Syringe [Lupron] |
| 1115472 | SCD | 1.5 ML leuprolide acetate 7.5 MG/ML Prefilled Syringe | 2639749 | Pediatric 1.5 ML leuprolide acetate 7.5 MG/ML Prefilled Syringe |
| 1115473 | SBD | 1.5 ML leuprolide acetate 7.5 MG/ML Prefilled Syringe [Lupron] | 2639750 | Pediatric 1.5 ML leuprolide acetate 7.5 MG/ML Prefilled Syringe [Lupron] |
As a reminder, Qualitative Distinction modifiers allow flexibility in the RxNorm model to create new RXCUIs as needed. See the RxNorm Technical Documentation for more information about Qualitative Distinction (QD) modifiers, which were first released in the August 2016 monthly release. For each SCD or SBD with a QD, there is an associated attribute in RXNSAT with the attribute name (ATN) of 'RXN_QUALITATIVE_DISTINCTION'.
Upcoming RxNorm Data Changes
As a courtesy to customers, this section provides advance notice of possible upcoming RxNorm data changes. More information about each change will be provided or repeated in the future. Please note that planned data changes and timelines may change if issues arise.
Test Files with New RxNorm Terminology Term Types (TTYs) Available July 3, 2023
As previously announced, RxNorm will add three new TTYs by fall/winter 2023 at the earliest. These new TTYs will improve the RxNorm model for medications using precise ingredients as the basis of strength substance.
To help stakeholders prepare for the change, test files with new TTYs will be available on July 3, 2023. A URL to the test files will be available in the RxNorm July monthly release announcement email and the RxNorm July 2023 full release notes, barring any issues. The test files will be available through the end of August 2023.
The new TTYs that will be added are:
- Semantic Clinical Drug Form Precise (SCDFP)
- Semantic Clinical Dose Form Group Precise (SCDGP)
- Semantic Branded Drug Form Precise (SBDFP)
The new TTYs will have the following relationships in RXNREL.RRF:
SCDFP
- isa/inverse_isa – SCDGP
- has_form/form_of – SCDF
- has_boss/boss_of – PIN/IN (RO)
- has tradename/tradename_of – SBDFP
- isa/inverse_isa (RN/RB) – SCD
SBDFP
- has_form/form_of – SBDF
- tradename_of/has tradename – SCDFP
- isa/inverse_isa (RN/RB) – SBD
SCDGP
- has_form/form_of – SCDG
- is_a/inverse_isa – SCDFP
- has_tradename/tradename_of – SBDG
Data Counts
| Term Type or Attribute | Number |
|---|---|
| Active GPCKs | 508 |
| Active BPCKs | 609 |
| Active SCDs | 17238 |
| Active SBDs | 9489 |
| Active RXNORM MINs | 3779 |
| Active RXNORM INs | 14116 |
| Active RXNORM PINs | 3376 |
| Active RXNORM BNs | 5094 |
| Active RXNORM DFs | 123 |
| Obsolete GPCKs | 242 |
| Obsolete BPCKs | 231 |
| Obsolete SCDs | 19101 |
| Obsolete SBDs | 11454 |
| Obsolete RXNORM MINs | 0 |
| Obsolete RXNORM INs | 0 |
| Obsolete RXNORM PINs | 0 |
| Obsolete RXNORM BNs | 6298 |
| Obsolete RXNORM DFs | 63 |
| Editor-suppressed SCDs | 1957 |
| Editor-suppressed SBDs | 1623 |
| SAB=RXNORM NDCs | 252633 |
| Distinct SAB=RXNORM NDCs | 252633 |
Last Reviewed: July 3, 2023