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Unified Medical Language System® (UMLS®)

RxNorm Release Notes

December Release - 12/07/2020

For additional information about RxNorm releases, including scripts for loading the RxNorm data into Oracle and MySQL databases, read the RxNorm Technical Documentation.


The following sources with version names in bold have been updated since the previous RxNorm release:

Source NameSABVersion
Vaccines Administered CVX CVX_2020_11_16
DrugBank DRUGBANK DRUGBANK5.0_2020_10_29
Gold Standard Drug Database GS GS_2020_11_17
Multum MediSource Lexicon MMSL MMSL_2020_11_01
Micromedex RED BOOK MMX MMX_2020_11_16
Medical Subject Headings (MeSH) MSH MSH2021_2020_07_16
FDA Structured Product Labels MTHSPL MTHSPL_2020_11_30
FDB MedKnowledge (formerly NDDF Plus) NDDF NDDF_2020_11_18
RxNorm normalized names and codes RXNORM RXNORM_20AA_201207F
Veterans Health Administration National Drug File VANDF VANDF_2020_10_31

The following sources have not been updated since the previous RxNorm release:

Source NameSABVersion
Anatomical Therapeutic Chemical Classification System ATC ATC_2020
CMS Formulary Reference File MTHCMSFRF MTHCMSFRF_2020
US Edition of SNOMED CT (drug information) SNOMEDCT_US SNOMEDCT_US_2020_07_31
USP Compendial Nomenclature USP USP_2020_02_06

*Reminder: As of October 2017, Medi-Span data will not be included in the RxNorm or UMLS releases. If you have questions about Medi-Span, please contact:

COVID-19 Vaccines

The RxNorm Content Team is closely monitoring the status of Coronavirus Disease 2019 (COVID-19) vaccines and COVID-19 related medications.  When they are approved by the U.S. Food & Drug Administration (FDA), the RxNorm Content Team will add standardized names and codes as quickly as possible. However, no set timeframe is available. Get more COVID-19 information from the FDA:


Data Changes

REMINDER: New Casirivimab and Imdevimab SCDs

Casirivimab and imdevimab are monoclonal antibodies that are to be administered together for the treatment of COVID-19. Casirivimab and imdevimab are each available in two different vial sizes.

NOTE: Currently, we do not have a National Drug Code (NDC) for a packaged product of casirivimab and imdevimab together. Therefore, generic pack (GPCK) names are not available at this time.


Here are the new casirivimab Semantic Clinical Drug (SCD) names, RxNorm Concept Unique Identifier (RXCUI), and NDC:

  • SCD: 11.1 ML casirivimab 120 MG/ML Injection
  • RXCUI: 2465246
  • NDC: 61755002401


  • SCD: 2.5 ML casirivimab 120 MG/ML Injection
  • RXCUI: 2465248
  • NDC: 61755002601


Here are the new imdevimab SCD names, RXCUI, and NDC:

  • SCD: 11.1 ML imdevimab 120 MG/ML Injection
  • RXCUI: 2465253
  • NDC: 61755002501


  • SCD: 2.5 ML imdevimab 120 MG/ML Injection
  • RXCUI: 2465255
  • NDC: 61755002701

Get more information about Emergency Use Authorization (EUA) of casirivimab and imdevimab from the FDA:

Get more information about RxNorm’s policy change on investigational drugs from NLM:


UMLSAUI & UMLSCUI Attributes Deleted 

The UMLSAUI and UMLSCUI were deleted from the release files, specifically RXNSAT.RRF, RXNDOC.RRF in the full monthly release, and RXNSAT.RRF in the Current Prescribable Content Monthly release. Users can obtain the UMLSAUI and UMLSCUI directly from the Metathesaurus if needed. Also, UMLS Metathesaurus data is no longer updated as of the November 2020 monthly release. See the RxNorm Release Notes 11/02/2020 for more information.


Data Counts

Term Type or AttributeNumber
Active GPCKs430
Active BPCKs516
Active SCDs16864
Active SBDs9416
Active RXNORM MINs3735
Active RXNORM INs13070
Active RXNORM PINs3063
Active RXNORM BNs5122
Active RXNORM DFs121
Obsolete GPCKs230
Obsolete BPCKs197
Obsolete SCDs18250
Obsolete SBDs10723
Obsolete RXNORM MINs0
Obsolete RXNORM INs0
Obsolete RXNORM PINs0
Obsolete RXNORM BNs6100
Obsolete RXNORM DFs63
Editor-suppressed SCDs1792
Editor-suppressed SBDs1479
Distinct SAB=RXNORM NDCs247679

Last Reviewed: December 7, 2020