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Unified Medical Language System® (UMLS®)

2012AB RxNorm Source Information




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VSAB:  RXNORM_12AA_120904F

Notes:

RxNorm, a standardized nomenclature for clinical drugs, is produced by the National Library of Medicine. Data files are released monthly and available by download. Within each Metathesaurus cycle, RxNorm is updated multiple times. This document reflects the latest cumulative update. The scope of RxNorm is determined by the combined scope of its source vocabularies which include the following:

Sources Description
GS_2012_08_01 Gold Standard Drug Database
MDDB_2012_08_01 Master Drug Data Base. Medi-Span, a division of Wolters Kluwer Health
MMSL_2012_08_01 Multum MediSource Lexicon
MMX_2012_07_30 Micromedex RED BOOK
MSH2012_2011_09_09 Medical Subject Headings
MTHFDA_2011_06_01 FDA National Drug Code Directory
MTHSPL_2012_08_28 FDA Structured Product Labels
NDDF_2012_08_01 FDB MedKnowledge
NDFRT_2012_09_04
National Drug File
RXNORM_12AA_120904F
RxNorm Vocabulary
SNOMEDCT_2012_01_31 SNOMED Clinical Terms (drug information)
VANDF_2012_07_27 Veterans Health Administration National Drug File

Note: Selected portions of MSH and SNOMEDCT are included in the RxNorm release files, however, they are not processed as part of RxNorm for the Metathesaurus except in assigning RXCUI and RXAUI attributes. All MSH or SNOMEDCT data in the Metathesaurus comes directly from that source's data files. This document describes how the RxNorm release files (RXN*RRF) are processed for representation in the UMLS Metathesaurus.  It does not cover processing of individual source vocabularies for inclusion in RxNorm. 

Summary of Changes

No changes were made to the RXNORM format itself or to Metathesaurus source processing for 2012AB.  Data changes include the following:

1. New ATN = RXTERM_FORM. The RxTerm dose form name for this drug. SAB = RXNORM.

2. New RELA|RELA inverse:
  • contraindicated_with_disease|disease_with_contraindication
  • has_contraindicated_drug|drug_contraindicated_for
     Note: RELA = has_contraindicated_drug replaces the dropped RELA = contraindicated_drug.

3. SAB = NDDF, formerly known as NDDF Plus, is now called FDB MedKnowledge.

4. Homeopathic atoms from SAB = MTHSPL are included in this release.

5. MTHFDA is included in each Metathesaurus release as part of RxNorm, however, it was not updated in this version. MTHFDA was last updated in 2011.

Source Provided Files:

RXNORM data files are released monthly and available by download.

File Name Description
RXNCONSO.RRF Concept and source information.
RXNDOC.RRF Abbreviated values.
RXNREL.RRF Relationship and merge information.
RXNSAB.RRF Source information.
RXNSAT.RRF Attribute information.
RXNSTY.RRF Semantic type information.
RXNATOMARCHIVE.RRF Archive data. Not used.
RXNCUICHANGES.RRF CUI changes. Not used.
RXNCUI.RRF Retired CUIs.
RXNCONSOOCD.RRF OCD concept and source information.
RXNASATOCD.RRF OCD simple concept and atom attribute information.
RXNSTYOCD.RRF OCD semantic type.

Identifiers:

  • CODE: RXNCONSO.CODE
  • SAUI: RXNCONSO.RXAUI for RXNORM atoms; RXNCONSO.SAUI for other sources. (Currently SAUI is blank for other sources).
  • SCUI: RXNCONSO.RXCUI for RXNORM atoms; RXNCONSO.SCUI for other sources. (Currently SCUI is blank for other sources except NDFRT).
  • SDUI: RXNCONSO.SDUI (Currently always blank).

Atoms (MRCONSO):

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Term Type

Term types are extracted from field 13 of RXNCONSO.RRF and RXNCONSOOCD.RRF.

Suppressibility

For many RxNorm and subsource termtypes, the suppressibility value can be either "O" or "N". For all others, the value is "N". Suppressibility values are extracted from field 17 of RXNCONSO.RRF and RXNCONSOOCD.RRF.

In addition, source NDC attributes may have SUPPRESS="O". 


Attributes (MRSAT):

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All attribute names and their values are extracted from field 9 and 11 of RXNSAT.RRF and RXNSATOCD.RRF except for RXCUI and RXAUI which are created using RXNCONSO.RRF.


Definitions (MRDEF):

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There are no DEFINITIONS with SAB = "RXNORM".   NDFRT does contribute a small number of DEFINITIONS to MRDEF.RRF.


Relationships (MRREL):

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All relationships are extracted from field 4 (REL) and field 8 (RELA) of RXNREL.RRF. 

Note:  In the table below, where reasonable we have supplied term types involved in the listed relationships.  For sources that do not have "semantic term types" (e.g. NDFRT uses "HT" and "PT," which are based on the structure of the source, rather than types like "IN" which is derived from the meaning of the concept), these term types may not apply.

Source Relationship Relationship Label
Inverse Relationship Label
Description
NDFRT CHD
PAR
(no rela) CREATED from the "PAR" relationships in RXNREL.RRF.
Currently, NDFRT is the only RXNORM source with a hierarchy.
RXNORM RB
RN
contained_in
contains
Connects the "SBD", "SCD" with its drug delivery device.
RXNORM RB
RN
has_form
form_of
Connects the "PIN" with its "IN".
RXNORM RB
RN
has_quantified_form
quantified_form_of
Creates relationships using the "SBD" or "SCD".
RXNORM RB
RN
has_tradename
tradename_of
Connects the branded name with the generic or clinical name.
RXNORM
MMSL
VANDF
RB
RN
inverse_isa
isa
Connects the "PT" with its clinical drug name and connects the "SCD" & "SBD" to its drug form.
RXNORM RB
RN
precise_ingredient_of
has_precise_ingredient
Connects the "BN" with its "PIN".
RXNORM RO precise_ingredient_of
has_precise_ingredient
Connects the "SCDC" with its "PIN".
NDFRT
RO
active_metabolites_of
has_active_metabolites
Connects a concept of "INGREDIENT_KIND" with a concept of "DRUG_KIND"
NDFRT
RO
chemical_structure_of
has_chemical_structure
Connects a concept of "INGREDIENT_KIND" with a concept of "DRUG_KIND"
RXNORM RO consists_of
constitutes
Connects the "SCD", "SBD" with its drug component.
MMSL RO contained_in
contains
Connects "GN" atoms with other "GN" atoms.
NDFRT
RO
contraindicated_with_disease
disease_with_contraindication
Connects a concept of "DRUG_KIND" with a concept of "DISEASE_KIND"
NDFRT
RO
has_contraindicated_drug
drug_contraindicated_for
Connects a concept of "DISEASE_KIND" with a concept of "DRUG_KIND"
NDFRT
RO
contraindicating_class_of
has_contraindicating_class
Connects a concept of "INGREDIENT_KIND" with a concept of "DRUG_KIND"
NDFRT
RO
contraindicating_mechanism_of_action
has_contraindicating_mechanism_of_action
Connects a concept of "MECHANISM_OF_ACTION_KIND" with a concept of "DRUG_KIND"
NDFRT
RO
contraindicating_physiologic_effect
has_contraindicating_physiologic_effect
Connects a concept of "PHYSIOLOGIC_EFFECT_KIND" with a concept of "DRUG_KIND"
RXNORM
RO
doseformgroup_of
has_doseformgroup
Connects the "SCDG" and "SBDG" with the dose form group.
RXNORM
NDDF
NDFRT
RO dose_form_of
has_dose_form
Connects the "SCD", "SCDF", "SBD", and "SBDF" with the dose form.
NDFRT
RO
effect_may_be_inhibited_by
may_inhibit_effect_of
Connects two concepts of "DRUG_KIND"
RXNORM
RO included_in
includes
Connects the drug name with its Metathesaurus created name.
NDFRT
RO
induces
induced_by
Connects a concept of "DRUG_KIND" with a concept of "DISEASE_KIND"
RXNORM
MMSL
MTHSPL
NDDF
NDFRT
VANDF
RO ingredient_of
has_ingredient
Connects the "SCDF", "SCDC" to its ingredients; connects the "SBD", "SBDC", "SBDF" to its fully-specified drug brand name.
RXNORM
RO
ingredients_of
has_ingredients
Connects "SCD" with "MIN"
NDFRT
RO
may_diagnose
may_be_diagnosed_by
Connects a concept of "DRUG_KIND" with a concept of "DISEASE_KIND"
NDFRT
RO
may_prevent
may_be_prevented_by
Connects a concept of "DRUG_KIND" with a concept of "DISEASE_KIND"
NDFRT
RO
may_treat
may_be_treated_by
Connects a concept of "DRUG_KIND" with a concept of "DISEASE_KIND"
NDFRT
RO
mechanism_of_action_of
has_mechanism_of_action
Connects a concept of "MECHANISM_OF_ACTION_KIND" with a concept of "DRUG_KIND"
NDFRT
RO
metabolic_site_of
site_of_metabolism
Connects a concept of "PHARMACOKINETICS_KIND" with a concept of "DRUG_KIND"
RXNORM
RO
part_of
has_part
Connects "IN" or "PIN" with "MIN"
RXNORM
RO
participates_in
has_participant
Connects a concept of "DRUG_KIND" with a concept of "DRUG_INTERACTION_KIND"
NDFRT
RO
pharmacokinetics_of
has_pharmacokinetics
Connects a concept of "PHARMACOKINETICS_KIND" with a concept of "DRUG_KIND"
NDFRT
RO
physiologic_effect_of
has_physiologic_effect
Connects a concept of "PHYSIOLOGIC_EFFECT_KIND" with a concept of "DRUG_KIND"
RXNORM
RO
precise_ingredient_of
has_precise_ingredient
Connects "PIN" with "SCDC"
NDFRT
RO
product_component_of
has_product_component
Connects a product ([VA Product]) with its components
RXNORM RO reformulated_to
reformulation_of
Creates relationships using "BN".
NDFRT
RO
therapeutic_class_of
has_therapeutic_class
Connects a concept of "THERAPEUTIC_CATEGORY_KIND" with a concept of "DRUG_KIND"
RXNORM
SY
(no rela)
Connects RXNORM atoms to other sources
NDFRT
VANDF
SY has_print_name/print_name_of Connects the "AB" to its clinical drug name or its Metathesaurus created name.

Mappings (MRMAP):

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There are no mappings present in RxNorm.