Unified Medical Language System^® (UMLS^®)

2012AB RxNorm Source Information

Skip to: Atoms, Attributes, Definitions, Relationships, Mappings

VSAB: RXNORM_12AA_120904F

Notes:

RxNorm, a standardized nomenclature for clinical drugs, is produced by the National Library of Medicine. Data files are released monthly and available by download. Within each Metathesaurus cycle, RxNorm is updated multiple times. This document reflects the latest cumulative update. The scope of RxNorm is determined by the combined scope of its source vocabularies which include the following:

Sources	Description
GS_2012_08_01	Gold Standard Drug Database
MDDB_2012_08_01	Master Drug Data Base. Medi-Span, a division of Wolters Kluwer Health
MMSL_2012_08_01	Multum MediSource Lexicon
MMX_2012_07_30	Micromedex RED BOOK
MSH2012_2011_09_09	Medical Subject Headings
MTHFDA_2011_06_01	FDA National Drug Code Directory
MTHSPL_2012_08_28	FDA Structured Product Labels
NDDF_2012_08_01	FDB MedKnowledge
NDFRT_2012_09_04	National Drug File
RXNORM_12AA_120904F	RxNorm Vocabulary
SNOMEDCT_2012_01_31	SNOMED Clinical Terms (drug information)
VANDF_2012_07_27	Veterans Health Administration National Drug File

Note: Selected portions of MSH and SNOMEDCT are included in the RxNorm release files, however, they are not processed as part of RxNorm for the Metathesaurus except in assigning RXCUI and RXAUI attributes. All MSH or SNOMEDCT data in the Metathesaurus comes directly from that source's data files. This document describes how the RxNorm release files (RXN*RRF) are processed for representation in the UMLS Metathesaurus. It does not cover processing of individual source vocabularies for inclusion in RxNorm.

Summary of Changes

No changes were made to the RXNORM format itself or to Metathesaurus source processing for 2012AB. Data changes include the following:

1. New ATN = RXTERM_FORM. The RxTerm dose form name for this drug. SAB = RXNORM.

2. New RELA|RELA inverse:

contraindicated_with_disease|disease_with_contraindication
has_contraindicated_drug|drug_contraindicated_for

Note: RELA = has_contraindicated_drug replaces the dropped RELA = contraindicated_drug.

3. SAB = NDDF, formerly known as NDDF Plus, is now called FDB MedKnowledge.

4. Homeopathic atoms from SAB = MTHSPL are included in this release.

5. MTHFDA is included in each Metathesaurus release as part of RxNorm, however, it was not updated in this version. MTHFDA was last updated in 2011.

Source Provided Files:

RXNORM data files are released monthly and available by download.

File Name	Description
RXNCONSO.RRF	Concept and source information.
RXNDOC.RRF	Abbreviated values.
RXNREL.RRF	Relationship and merge information.
RXNSAB.RRF	Source information.
RXNSAT.RRF	Attribute information.
RXNSTY.RRF	Semantic type information.
RXNATOMARCHIVE.RRF	Archive data. Not used.
RXNCUICHANGES.RRF	CUI changes. Not used.
RXNCUI.RRF	Retired CUIs.
RXNCONSOOCD.RRF	OCD concept and source information.
RXNASATOCD.RRF	OCD simple concept and atom attribute information.
RXNSTYOCD.RRF	OCD semantic type.

Identifiers:

CODE: RXNCONSO.CODE
SAUI: RXNCONSO.RXAUI for RXNORM atoms; RXNCONSO.SAUI for other sources. (Currently SAUI is blank for other sources).
SCUI: RXNCONSO.RXCUI for RXNORM atoms; RXNCONSO.SCUI for other sources. (Currently SCUI is blank for other sources except NDFRT).
SDUI: RXNCONSO.SDUI (Currently always blank).

Atoms (MRCONSO):

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Term Type

Term types are extracted from field 13 of RXNCONSO.RRF and RXNCONSOOCD.RRF.

Suppressibility

For many RxNorm and subsource termtypes, the suppressibility value can be either "O" or "N". For all others, the value is "N". Suppressibility values are extracted from field 17 of RXNCONSO.RRF and RXNCONSOOCD.RRF.

In addition, source NDC attributes may have SUPPRESS="O".

Attributes (MRSAT):

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All attribute names and their values are extracted from field 9 and 11 of RXNSAT.RRF and RXNSATOCD.RRF except for RXCUI and RXAUI which are created using RXNCONSO.RRF.

Definitions (MRDEF):

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There are no DEFINITIONS with SAB = "RXNORM". NDFRT does contribute a small number of DEFINITIONS to MRDEF.RRF.

Relationships (MRREL):

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All relationships are extracted from field 4 (REL) and field 8 (RELA) of RXNREL.RRF.

Note: In the table below, where reasonable we have supplied term types involved in the listed relationships. For sources that do not have "semantic term types" (e.g. NDFRT uses "HT" and "PT," which are based on the structure of the source, rather than types like "IN" which is derived from the meaning of the concept), these term types may not apply.

Source	Relationship	Relationship Label Inverse Relationship Label	Description
NDFRT	CHD PAR	(no rela)	CREATED from the "PAR" relationships in RXNREL.RRF. Currently, NDFRT is the only RXNORM source with a hierarchy.
RXNORM	RB RN	contained_in contains	Connects the "SBD", "SCD" with its drug delivery device.
RXNORM	RB RN	has_form form_of	Connects the "PIN" with its "IN".
RXNORM	RB RN	has_quantified_form quantified_form_of	Creates relationships using the "SBD" or "SCD".
RXNORM	RB RN	has_tradename tradename_of	Connects the branded name with the generic or clinical name.
RXNORM MMSL VANDF	RB RN	inverse_isa isa	Connects the "PT" with its clinical drug name and connects the "SCD" & "SBD" to its drug form.
RXNORM	RB RN	precise_ingredient_of has_precise_ingredient	Connects the "BN" with its "PIN".
RXNORM	RO	precise_ingredient_of has_precise_ingredient	Connects the "SCDC" with its "PIN".
NDFRT	RO	active_metabolites_of has_active_metabolites	Connects a concept of "INGREDIENT_KIND" with a concept of "DRUG_KIND"
NDFRT	RO	chemical_structure_of has_chemical_structure	Connects a concept of "INGREDIENT_KIND" with a concept of "DRUG_KIND"
RXNORM	RO	consists_of constitutes	Connects the "SCD", "SBD" with its drug component.
MMSL	RO	contained_in contains	Connects "GN" atoms with other "GN" atoms.
NDFRT	RO	contraindicated_with_disease disease_with_contraindication	Connects a concept of "DRUG_KIND" with a concept of "DISEASE_KIND"
NDFRT	RO	has_contraindicated_drug drug_contraindicated_for	Connects a concept of "DISEASE_KIND" with a concept of "DRUG_KIND"
NDFRT	RO	contraindicating_class_of has_contraindicating_class	Connects a concept of "INGREDIENT_KIND" with a concept of "DRUG_KIND"
NDFRT	RO	contraindicating_mechanism_of_action has_contraindicating_mechanism_of_action	Connects a concept of "MECHANISM_OF_ACTION_KIND" with a concept of "DRUG_KIND"
NDFRT	RO	contraindicating_physiologic_effect has_contraindicating_physiologic_effect	Connects a concept of "PHYSIOLOGIC_EFFECT_KIND" with a concept of "DRUG_KIND"
RXNORM	RO	doseformgroup_of has_doseformgroup	Connects the "SCDG" and "SBDG" with the dose form group.
RXNORM NDDF NDFRT	RO	dose_form_of has_dose_form	Connects the "SCD", "SCDF", "SBD", and "SBDF" with the dose form.
NDFRT	RO	effect_may_be_inhibited_by may_inhibit_effect_of	Connects two concepts of "DRUG_KIND"
RXNORM	RO	included_in includes	Connects the drug name with its Metathesaurus created name.
NDFRT	RO	induces induced_by	Connects a concept of "DRUG_KIND" with a concept of "DISEASE_KIND"
RXNORM MMSL MTHSPL NDDF NDFRT VANDF	RO	ingredient_of has_ingredient	Connects the "SCDF", "SCDC" to its ingredients; connects the "SBD", "SBDC", "SBDF" to its fully-specified drug brand name.
RXNORM	RO	ingredients_of has_ingredients	Connects "SCD" with "MIN"
NDFRT	RO	may_diagnose may_be_diagnosed_by	Connects a concept of "DRUG_KIND" with a concept of "DISEASE_KIND"
NDFRT	RO	may_prevent may_be_prevented_by	Connects a concept of "DRUG_KIND" with a concept of "DISEASE_KIND"
NDFRT	RO	may_treat may_be_treated_by	Connects a concept of "DRUG_KIND" with a concept of "DISEASE_KIND"
NDFRT	RO	mechanism_of_action_of has_mechanism_of_action	Connects a concept of "MECHANISM_OF_ACTION_KIND" with a concept of "DRUG_KIND"
NDFRT	RO	metabolic_site_of site_of_metabolism	Connects a concept of "PHARMACOKINETICS_KIND" with a concept of "DRUG_KIND"
RXNORM	RO	part_of has_part	Connects "IN" or "PIN" with "MIN"
RXNORM	RO	participates_in has_participant	Connects a concept of "DRUG_KIND" with a concept of "DRUG_INTERACTION_KIND"
NDFRT	RO	pharmacokinetics_of has_pharmacokinetics	Connects a concept of "PHARMACOKINETICS_KIND" with a concept of "DRUG_KIND"
NDFRT	RO	physiologic_effect_of has_physiologic_effect	Connects a concept of "PHYSIOLOGIC_EFFECT_KIND" with a concept of "DRUG_KIND"
RXNORM	RO	precise_ingredient_of has_precise_ingredient	Connects "PIN" with "SCDC"
NDFRT	RO	product_component_of has_product_component	Connects a product ([VA Product]) with its components
RXNORM	RO	reformulated_to reformulation_of	Creates relationships using "BN".
NDFRT	RO	therapeutic_class_of has_therapeutic_class	Connects a concept of "THERAPEUTIC_CATEGORY_KIND" with a concept of "DRUG_KIND"
RXNORM	SY	(no rela)	Connects RXNORM atoms to other sources
NDFRT VANDF	SY	has_print_name/print_name_of	Connects the "AB" to its clinical drug name or its Metathesaurus created name.

Mappings (MRMAP):

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There are no mappings present in RxNorm.

Unified Medical Language System® (UMLS®)

2012AB RxNorm Source Information

Notes:

Summary of Changes

Identifiers:

Atoms (MRCONSO):

Term Type

Suppressibility

Attributes (MRSAT):

Definitions (MRDEF):

Relationships (MRREL):

Mappings (MRMAP):

Unified Medical Language System^® (UMLS^®)