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Unified Medical Language System® (UMLS®)

2014AB UMLS RXNORM Source Information

This page lists UMLS Metathesaurus data elements and traces them back to the specific source data that populates them.


Skip to: Atoms, Attributes, Definitions, Relationships, Mappings

VSAB:  RXNORM_14AA_140902F

Notes:

RxNorm, a standardized nomenclature for clinical drugs, is produced by the National Library of Medicine. Data files are released monthly and available by download. Within each Metathesaurus cycle, RxNorm is updated multiple times. This document reflects the latest cumulative update. The scope of RxNorm is determined by the combined scope of its source vocabularies which include the following:

Sources Description
ATC_2014_14_09_02 Anatomical Therapeutic Chemical Classification System
GS_2014_08_01 Gold Standard Drug Database
MDDB_2014_07_30 Master Drug Data Base. Medi-Span, a division of Wolters Kluwer Health
MMSL_2014_08_01 Multum MediSource Lexicon
MMX_2014_08_04 Micromedex RED BOOK
MTHFDA_2011_06_01_13_05_06 FDA National Drug Code Directory
MTHSPL_2014_08_25 FDA Structured Product Labels
NDDF_2014_08_06 FDB MedKnowledge
NDFRT_2014_09_02 National Drug File
NDFRT_FMTSME_2014_09_02 National Drug File - FMTSME
NDFRT_FDASPL:_2014_09_02 National Drug File - FDASPL
RXNORM_14AA_140902F RxNorm Vocabulary
VANDF_2014_07_17 Veterans Health Administration National Drug File

Note: Selected portions of MSH and SNOMEDCT are included in the RxNorm release files, however, they are not processed as part of RxNorm for the Metathesaurus except in assigning RXCUI and RXAUI attributes. All MSH or SNOMEDCT data in the Metathesaurus comes directly from that source's data files. This document describes how the RxNorm release files (RXN*RRF) are processed for representation in the UMLS Metathesaurus.  It does not cover processing of individual source vocabularies for inclusion in RxNorm. 

MTHFDA is included in each Metathesaurus release as part of RxNorm, however, it was not updated in this version. MTHFDA was last updated in 2011.

Summary of Changes

No changes were made to the RXNORM format itself or to Metathesaurus source processing for 2014AB.  Data changes include the following:

Subsources:
NOTE: These subsources provide relationship data only and no atoms.
     Status       SAB   Description
     New     
NDFRT_FMTSME_2014_09_02     
National Drug File - FMTSME
     New     
NDFRT_FDASPL_2014_09_02     
National Drug File - FDASPL

Atoms:
     Status       TTY   SAB
     New     
FN
NDRFT_2014_09_02
     New     
HT
NDRFT_2014_09_02
     New
PSN
RXNORM_14AA_140902F

Relationships: 
Status Relationship Inverse SAB
     New
active_ingredient_of
has_active_ingredient   
MTHSPL_2014_08_25
     New     
active_metabolites_of    
has_active_metabolites
NDFRT_2014_09_02
     New
active_moiety_of
has_active_moiety   
MTHSPL_2014_08_25
     New
chemical_structure_of
has_chemical_structure   
NDFRT_FDASPL_2014_09_02, NDFRT_FMTSME_2014_09_02
     New
contraindicated_with_disease
disease_with_contraindication   
NDFRT_2014_09_02
     New
contraindicating_class_of
has_contraindicating_class   
NDFRT_2014_09_02
     New
contraindicating_mechanism_of_action_of
has_contraindicating_mechanism_of   
NDFRT_2014_09_02
     New
contraindicating_physiologic_effect_of
has_contraindicating_physiologic_e   
NDFRT_2014_09_02
     New
effect_may_be_inhibited_by
may_inhibit_effect_of   
NDFRT_2014_09_02
     New
has_active_ingredient
active_ingredient_of   
MTHSPL_2014_08_25
     New
has_active_metabolites
active_metabolites_of   
NDFRT_2014_09_02
     New
has_active_moiety
active_moiety_of   
MTHSPL_2014_08_25
     New
has_chemical_structure
chemical_structure_of   
NDFRT_FDASPL_2014_09_02, NDFRT_FMTSME_2014_09_02
     New
has_contraindicated_drug
drug_contraindicated_for   
NDFRT_2014_09_02
     New
has_contraindicating_class
contraindicating_class_of   
NDFRT_2014_09_02
     New
has_contraindicating_mechanism_of_action
contraindicating_mechanism_of_action_of   
NDFRT_2014_09_02
     New
has_contraindicating_physiologic_effect
contraindicating_physiologic_effect_of   
NDFRT_2014_09_02
     New
has_inactive_ingredient
inactive_ingredient_of   
MTHSPL_2014_08_25
     New
has_mechanism_of_action
mechanism_of_action_of   
NDFRT_FDASPL_2014_09_02, NDFRT_FMTSME_2014_09_02
     New
has_pharmacokinetics
pharmacokinetics_of   
NDFRT_2014_09_02
     New
has_physiologic_effect
physiologic_effect_of   
NDFRT_2014_09_02, NDFRT_FDASPL_2014_09_02, NDFRT_FMTSME_2014_09_02
     New
has_product_component
product_component_of   
NDFRT_2014_09_02
     New
has_therapeutic_class
therapeutic_class_of   
NDFRT_FMTSME_2014_09_02
     New
inactive_ingredient_of
has_inactive_ingredient   
MTHSPL_2014_08_25
     New
induced_by
induces   
NDFRT_2014_09_02
     New
induces
induced_by   
NDFRT_2014_09_02
     New
may_be_diagnosed_by
may_diagnose   
NDFRT_2014_09_02, NDFRT_FMTSME_2014_09_02
     New
may_be_prevented_by
may_prevent   
NDFRT_2014_09_02, NDFRT_FMTSME_2014_09_02
     New
may_be_treated_by
may_treat   
NDFRT_2014_09_02, NDFRT_FMTSME_2014_09_02
     New
may_diagnose
may_be_diagnosed_by   
NDFRT_2014_09_02, NDFRT_FMTSME_2014_09_02
     New
may_inhibit_effect_of
effect_may_be_inhibited_by   
NDFRT_2014_09_02
     New
may_prevent
may_be_prevented_by   
NDFRT_2014_09_02, NDFRT_FMTSME_2014_09_02
     New
may_treat
may_be_treated_by   
NDFRT_2014_09_02, NDFRT_FMTSME_2014_09_02
     New
mechanism_of_action_of
has_mechanism_of_action   
NDFRT_2014_09_02, NDFRT_FDASPL_2014_09_02, NDFRT_FMTSME_2014_09_02
     New
metabolic_site_of
site_of_metabolism   
NDFRT_2014_09_02
     New
pharmacokinetics_of
has_pharmacokinetics   
NDFRT_2014_09_02
     New
physiologic_effect_of
has_physiologic_effect   
NDFRT_2014_09_02, NDFRT_FDASPL_2014_09_02, NDFRT_FMTSME_2014_09_02
     New
product_component_of
has_product_component   
NDFRT_2014_09_02
     New
site_of_metabolism
metabolic_site_of   
NDFRT_2014_09_02
     New
therapeutic_class_of
has_therapeutic_class   
NDFRT_FMTSME_2014_09_02

Attributes: 
Status ATN SAB
     New     
FDA_UNII_CODE     
NDFRT_2014_09_02
     New     
LEVEL     
NDFRT_2014_09_02
     New     
MESH_DEFINITION     
NDFRT_2014_09_02
     New     
MESH_DUI     
NDFRT_2014_09_02
     New     
MESH_NAME     
NDFRT_2014_09_02
     New     
MESH_UI     
NDFRT_2014_09_02
     New     
NDFRT_KIND     
NDFRT_2014_09_02
     New     
NDF_UNITS     
NDFRT_2014_09_02
     New     
NUI     
NDFRT_2014_09_02
     New     
PREMARKET_APPLICATION     
MTHSPL_2014_08_25
     New     
SNOMED_CID     
NDFRT_2014_09_02
     New     
STRENGTH     
NDFRT_2014_09_02
     New     
VANDF_RECORD     
NDFRT_2014_09_02
     New     
VA_IEN     
NDFRT_2014_09_02
     New     
VUID     
NDFRT_2014_09_02
     Deprecated     
FDASRS     

     Deprecated     
UNII_CODE     


Source Provided Files:

RXNORM data files are released monthly and available by download.

File Name Description
RXNCONSO.RRF Concept and source information.
RXNDOC.RRF Abbreviated values.
RXNREL.RRF Relationship and merge information.
RXNSAB.RRF Source information.
RXNSAT.RRF Attribute information.
RXNSTY.RRF Semantic type information.
RXNATOMARCHIVE.RRF Archive data. Not used.
RXNCUICHANGES.RRF CUI changes. Not used.
RXNCUI.RRF Retired CUIs.
RXNCONSOOCD.RRF OCD concept and source information.
RXNASATOCD.RRF OCD simple concept and atom attribute information.
RXNSTYOCD.RRF OCD semantic type.

Identifiers:

  • CODE: RXNCONSO.CODE
  • SAUI: RXNCONSO.RXAUI for RXNORM atoms; RXNCONSO.SAUI for other sources. (Currently SAUI is blank for other sources).
  • SCUI: RXNCONSO.RXCUI for RXNORM atoms; RXNCONSO.SCUI for other sources. (Currently SCUI is blank for other sources except NDFRT).
  • SDUI: RXNCONSO.SDUI (Currently always blank).

Atoms (MRCONSO):

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Term Type

Term types are extracted from field 13 of RXNCONSO.RRF and RXNCONSOOCD.RRF.

Suppressibility

For many RxNorm and subsource termtypes, the suppressibility value can be either "O" or "N". For all others, the value is "N". Suppressibility values are extracted from field 17 of RXNCONSO.RRF and RXNCONSOOCD.RRF.

In addition, source NDC attributes may have SUPPRESS="O". 


Attributes (MRSAT):

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All attribute names and their values are extracted from field 9 and 11 of RXNSAT.RRF and RXNSATOCD.RRF except for RXCUI and RXAUI which are created using RXNCONSO.RRF.


Definitions (MRDEF):

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There are no DEFINITIONS with SAB = "RXNORM".   NDFRT does contribute a small number of DEFINITIONS to MRDEF.RRF.


Relationships (MRREL):

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All relationships are extracted from field 4 (REL) and field 8 (RELA) of RXNREL.RRF. 

Note:  In the table below, where reasonable we have supplied term types involved in the listed relationships.  For sources that do not have "semantic term types" (e.g. NDFRT uses "HT" and "PT," which are based on the structure of the source, rather than types like "IN" which is derived from the meaning of the concept), these term types may not apply.

Source Relationship Relationship Label
Inverse Relationship Label
Description
NDFRT CHD
PAR
(no rela) CREATED from the "PAR" relationships in RXNREL.RRF.
Currently, NDFRT is the only RXNORM source with a hierarchy.
RXNORM RB
RN
contained_in
contains
Connects the "SBD", "SCD" with its drug delivery device.
RXNORM RB
RN
has_form
form_of
Connects the "PIN" with its "IN".
RXNORM RB
RN
has_quantified_form
quantified_form_of
Creates relationships using the "SBD" or "SCD".
RXNORM RB
RN
has_tradename
tradename_of
Connects the branded name with the generic or clinical name.
RXNORM
MMSL
VANDF
RB
RN
inverse_isa
isa
Connects the "PT" with its clinical drug name and connects the "SCD" & "SBD" to its drug form.
RXNORM RB
RN
precise_ingredient_of
has_precise_ingredient
Connects the "BN" with its "PIN".
RXNORM RO precise_ingredient_of
has_precise_ingredient
Connects the "SCDC" with its "PIN".
RXNORM RO consists_of
constitutes
Connects the "SCD", "SBD" with its drug component.
MMSL RO contained_in
contains
Connects "GN" atoms with other "GN" atoms.
RXNORM
RO
doseformgroup_of
has_doseformgroup
Connects the "SCDG" and "SBDG" with the dose form group.
RXNORM
NDDF
NDFRT
RO dose_form_of
has_dose_form
Connects the "SCD", "SCDF", "SBD", and "SBDF" with the dose form.
RXNORM
RO included_in
includes
Connects the drug name with its Metathesaurus created name.
RXNORM
MMSL
MTHSPL
NDDF
NDFRT
VANDF
RO ingredient_of
has_ingredient
Connects the "SCDF", "SCDC" to its ingredients; connects the "SBD", "SBDC", "SBDF" to its fully-specified drug brand name.
RXNORM
RO
ingredients_of
has_ingredients
Connects "SCD" with "MIN"
NDFRT
RO
may_treat
may_be_treated_by
Connects a concept of "DRUG_KIND" with a concept of "DISEASE_KIND"
NDFRT
RO
mechanism_of_action_of
has_mechanism_of_action
Connects a concept of "MECHANISM_OF_ACTION_KIND" with a concept of "DRUG_KIND"
NDFRT
RO
metabolic_site_of
has_metabolic_site
Connects a concept of "PHARMACOKINETICS_KIND" with a concept of "DRUG_KIND"
RXNORM
RO
part_of
has_part
Connects "IN" or "PIN" with "MIN"
RXNORM
RO
precise_ingredient_of
has_precise_ingredient
Connects "PIN" with "SCDC"
RXNORM RO reformulated_to
reformulation_of
Creates relationships using "BN".
RXNORM
SY
(no rela)
Connects RXNORM atoms to other sources

Mappings (MRMAP):

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There are no mappings present in RxNorm.