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Unified Medical Language System (UMLS)

RXNORM (RXNORM) - Metathesaurus Representation


This page lists UMLS Metathesaurus data elements and traces them back to the specific source data that populates them.

Skip to: Atoms, Attributes, Definitions, Relationships, Mappings

VSAB: RXNORM_17AA_170905F

Notes:

RxNorm, a standardized nomenclature for clinical drugs, is produced by the National Library of Medicine. Data files are released monthly and available by download. Within each Metathesaurus cycle, RxNorm is updated multiple times. This document reflects the latest cumulative update. The scope of RxNorm is determined by the combined scope of its source vocabularies which include the following:

Sources Description
ATC_2017_17_09_05 Anatomical Therapeutic Chemical Classification System
CVX_2017_08_24 Vaccines Administered
DRUGBANK5.0_2017_08_01 DrugBank
GS_2017_08_02 Gold Standard Drug Database
MDDB_2017_08_02 Master Drug Data Base
MMSL_2017_08_01 Multum MediSource Lexicon
MMX_2017_08_07 Micromedex RED BOOK
MTHSPL_2017_08_25 Metathesaurus FDA Structured Product Labels
NDDF_2017_08_02 FDB MedKnowledge
NDFRT_2017_09_05 National Drug File
NDFRT_FDASPL_2017_09_05 National Drug File - FDASPL
NDFRT_FMTSME_2017_09_05 National Drug File - FMTSME
RXNORM_17AA_170905F RxNorm Vocabulary
VANDF_2017_07_20 Veterans Health Administration National Drug File

Note: Selected portions of MSH and SNOMEDCT are included in the RxNorm release files, however, they are not processed as part of RxNorm for the Metathesaurus except in assigning RXCUI and RXAUI attributes. All MSH or SNOMEDCT data in the Metathesaurus comes directly from that source's data files. This document describes how the RxNorm release files (RXN*RRF) are processed for representation in the UMLS Metathesaurus.  It does not cover processing of individual source vocabularies for inclusion in RxNorm. 

Summary of Changes

No changes were made to the RXNORM format itself or to Metathesaurus source processing for 2017AB.  Data changes include the following:

Attributes:
Status ATN SAB
     New      EXPORT_ONLY      MTHSPL_2017_08_25
     New      GPI      MDDB_2017_08_02
     New      GPPC      MDDB_2017_08_02
     New      HRI      MDDB_2017_08_02
     New      NON_VACCINE      CVX_2017_08_24

Term types:
Status TTY SAB
     New      BD      MDDB_2017_08_02
     New      IN      MDDB_2017_08_02
     New      MTH_RXN_BD      MDDB_2017_08_02
     New      MTH_RXN_CD      MDDB_2017_08_02

Source Provided Files:

RXNORM data files are released monthly and available by download.

File Name Description
RXNCONSO.RRF Concept and source information.
RXNDOC.RRF Abbreviated values.
RXNREL.RRF Relationship and merge information.
RXNSAB.RRF Source information.
RXNSAT.RRF Attribute information.
RXNSTY.RRF Semantic type information.
RXNATOMARCHIVE.RRF Archive data. Not used.
RXNCUICHANGES.RRF CUI changes. Not used.
RXNCUI.RRF Retired CUIs.

Identifiers:

  • CODE: RXNCONSO.CODE
  • SAUI: RXNCONSO.RXAUI for RXNORM atoms; RXNCONSO.SAUI for other sources. (Currently SAUI is blank for other sources).
  • SCUI: RXNCONSO.RXCUI for RXNORM atoms; RXNCONSO.SCUI for other sources. (Currently SCUI is blank for other sources except NDFRT).
  • SDUI: RXNCONSO.SDUI (Currently always blank).

Atoms (MRCONSO):


Term Type

Term types are extracted from field 13 of RXNCONSO.RRF.

Suppressibility

For many RxNorm and subsource termtypes, the suppressibility value can be either "O" or "N". For all others, the value is "N". Suppressibility values are extracted from field 17 of RXNCONSO.RRF.

In addition, source NDC attributes may have SUPPRESS="O".

Attributes (MRSAT):

All attribute names and their values are extracted from field 9 and 11 of RXNSAT.RRF except for RXCUI and RXAUI which are created using RXNCONSO.RRF.

Definitions (MRDEF):

There are no DEFINITIONS with SAB = "RXNORM".   NDFRT does contribute a small number of DEFINITIONS to MRDEF.RRF.

Relationships (MRREL):

All relationships are extracted from field 4 (REL) and field 8 (RELA) of RXNREL.RRF

Note:  In the table below, where reasonable we have supplied term types involved in the listed relationships.  For sources that do not have "semantic term types" (e.g. NDFRT uses "HT" and "PT," which are based on the structure of the source, rather than types like "IN" which is derived from the meaning of the concept), these term types may not apply.

Source Relationship Relationship Label
Inverse Relationship Label
Description
NDFRT CHD
PAR
(no rela) CREATED from the "PAR" relationships in RXNREL.RRF.
Currently, NDFRT is the only RXNORM source with a hierarchy.
RXNORM RB
RN
contained_in
contains
Connects the "SBD", "SCD" with its drug delivery device.
RXNORM RB
RN
has_form
form_of
Connects the "PIN" with its "IN".
RXNORM RB
RN
has_quantified_form
quantified_form_of
Creates relationships using the "SBD" or "SCD".
RXNORM RB
RN
has_tradename
tradename_of
Connects the branded name with the generic or clinical name.
RXNORM
MMSL
VANDF
RB
RN
inverse_isa
isa
Connects the "PT" with its clinical drug name and connects the "SCD" & "SBD" to its drug form.
RXNORM RB
RN
precise_ingredient_of
has_precise_ingredient
Connects the "BN" with its "PIN".
RXNORM RO precise_ingredient_of
has_precise_ingredient
Connects the "SCDC" with its "PIN".
RXNORM RO consists_of
constitutes
Connects the "SCD", "SBD" with its drug component.
MMSL RO contained_in
contains
Connects "GN" atoms with other "GN" atoms.
RXNORM
RO doseformgroup_of
has_doseformgroup
Connects the "SCDG" and "SBDG" with the dose form group.
RXNORM
NDDF
NDFRT
RO dose_form_of
has_dose_form
Connects the "SCD", "SCDF", "SBD", and "SBDF" with the dose form.
RXNORM RO included_in
includes
Connects the drug name with its Metathesaurus created name.
RXNORM
MMSL
MTHSPL
NDDF
NDFRT
VANDF
RO ingredient_of
has_ingredient
Connects the "SCDF", "SCDC" to its ingredients; connects the "SBD", "SBDC", "SBDF" to its fully-specified drug brand name.
RXNORM RO ingredients_of
has_ingredients
Connects "SCD" with "MIN"
NDFRT RO may_treat
may_be_treated_by
Connects a concept of "DRUG_KIND" with a concept of "DISEASE_KIND"
NDFRT RO mechanism_of_action_of
has_mechanism_of_action
Connects a concept of "MECHANISM_OF_ACTION_KIND" with a concept of "DRUG_KIND"
NDFRT RO metabolic_site_of
has_metabolic_site
Connects a concept of "PHARMACOKINETICS_KIND" with a concept of "DRUG_KIND"
RXNORM RO part_of
has_part
Connects "IN" or "PIN" with "MIN"
RXNORM RO precise_ingredient_of
has_precise_ingredient
Connects "PIN" with "SCDC"
RXNORM RO reformulated_to
reformulation_of
Creates relationships using "BN".
RXNORM SY (no rela) Connects RXNORM atoms to other sources

Mappings (MRMAP):

There are no mappings present in RxNorm.